Reactome | SEC16 complex binds SAR1B:GTP:SEC23:SEC24

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SEC16 complex binds SAR1B:GTP:SEC23:SEC24 Show undefined attributes

authored	[InstanceEdit:5683769] Rothfels, Karen, 2015-03-16
category	binding
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:5694416] Rothfels, Karen, 2015-05-21
dbId	5694417
displayName	SEC16 complex binds SAR1B:GTP:SEC23:SEC24
edited	[InstanceEdit:5688570] Rothfels, Karen, 2015-04-17
eventOf	[Pathway:R-HSA-204005] COPII-mediated vesicle transport - Homo sapiens
followingEvent	[Reaction:R-HSA-204008] SEC31:SEC13 and v-SNARE recruitment - Homo sapiens
input	[Complex:R-HSA-5694523] COPII cargo receptors:SAR1B:GTP:SEC23:SEC24 [endoplasmic reticulum membrane] [Complex:R-HSA-5694307] SEC16A:SEC16B [cytosol] [Complex:R-HSA-5694310] TFG hexamer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5685778] Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells [LiteratureReference:5685811] Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization [LiteratureReference:5685765] Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER [LiteratureReference:5685751] Insights into structural and regulatory roles of Sec16 in COPII vesicle formation at ER exit sites [LiteratureReference:5685773] SEC16 in COPII coat dynamics at ER exit sites [LiteratureReference:5688209] Sec16p potentiates the action of COPII proteins to bud transport vesicles [LiteratureReference:5688216] Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat [LiteratureReference:5688173] Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure [LiteratureReference:5688231] TFG-1 function in protein secretion and oncogenesis [LiteratureReference:5688222] TFG clusters COPII-coated transport carriers and promotes early secretory pathway organization
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SEC16 complex binds SAR1B:GTP:SEC23:SEC24
orthologousEvent	[Reaction:R-BTA-5694417] SEC16 complex binds SAR1B:GTP:SEC23:SEC24 - Bos taurus [Reaction:R-CEL-5694417] SEC16 complex binds SAR1B:GTP:SEC23:SEC24 - Caenorhabditis elegans [Reaction:R-GGA-5694417] SEC16 complex binds SAR1B:GTP:SEC23:SEC24 - Gallus gallus [Reaction:R-SSC-5694417] SEC16 complex binds SAR1B:GTP:SEC23:SEC24 - Sus scrofa [Reaction:R-CFA-5694417] SEC16 complex binds SAR1B:GTP:SEC23:SEC24 - Canis familiaris [Reaction:R-RNO-5694417] SEC16 complex binds SAR1B:GTP:SEC23:SEC24 - Rattus norvegicus [Reaction:R-MMU-5694417] SEC16 complex binds SAR1B:GTP:SEC23:SEC24 - Mus musculus
output	[Complex:R-HSA-5694339] COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-5694522] Inner coat assembly and cargo binding - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6791049] Gillespie, Marc E, 2015-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5694417
summation	[Summation:5694397] The multimeric SEC16 complex marks sites of ER exit (ERES) a...

Referrals

(hasEvent)	[Pathway:R-HSA-204005] COPII-mediated vesicle transport
(precedingEvent)	[Reaction:R-HSA-204008] SEC31:SEC13 and v-SNARE recruitment

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