SEC16 complex binds SAR1B:GTP:SEC23:SEC24

Stable Identifier
Homo sapiens
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The multimeric SEC16 complex marks sites of ER exit (ERES) and helps to localize nascent COPII coat complexes through interaction with SEC23 and SAR1 (Battacharyya et al, 2007; Watson et al, 2006; Hughes et al, 2009; Yorimitsu and Sato, 2012; reviewed in Sprangers and Rabouille, 2015). SEC16 may help to prevent premature dissociation of the COPII coats after activation of SEC13 GTPase (Supek et al, 2002; Kung et al, 2012). SEC16 functions with hexameric TFG1, which is recruited to the ERES through direct interaction with SEC16 and is required for cargo traffic out of the ER and for organization of the ER-to-ERGIC boundary (Witte et al, 2001; Beetz et al, 2012; Johnson et al, 2015).

Literature References
PubMed ID Title Journal Year
22157747 Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat

Pagant, S, Kung, LF, D'Arcangelo, JG, Hamamoto, S, Miller, EA, Schekman, R, Reid, RJ, Futai, E, Buchanan, R, Snapp, EL, Rothstein, R, Dittmar, JC

EMBO J. 2012
23479643 Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure

Saxena, R, Schuh, AL, Altmüller, J, Beetz, C, Nürnberg, P, Audhya, A, Thiele, H, Chapman, ER, Nürnberg, G, Bomba-Warczak, E, Thakur, S, Varga, RE, Fothergill, T, Dent, EW, Johnson, A, Hertel, N

Proc. Natl. Acad. Sci. U.S.A. 2013
25619252 SEC16 in COPII coat dynamics at ER exit sites

Rabouille, C, Sprangers, J

Biochem. Soc. Trans. 2015
25586378 TFG clusters COPII-coated transport carriers and promotes early secretory pathway organization

Audhya, A, Otegui, MS, Bhattacharya, N, Hanna, M, Schuh, AL, Wang, L, Stagg, SM, Pennington, JG, Johnson, A

EMBO J. 2015
12235121 Sec16p potentiates the action of COPII proteins to bud transport vesicles

Madden, DT, Orci, L, Hamamoto, S, Supek, F, Schekman, R

J. Cell Biol. 2002
17192411 Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization

Bhattacharyya, D, Glick, BS

Mol. Biol. Cell 2007
17005010 Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells

Stephens, DJ, Palmer, KJ, Townley, AK, Koka, P, Watson, P

Traffic 2006
19638414 Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER

Carter, DA, Verkade, P, Schmidt, K, Stephens, DJ, Mantell, J, Johnson, A, Palmer, KJ, Hughes, H, Budnik, A, Noakes, C, Watson, P

J. Cell. Sci. 2009
21478858 TFG-1 function in protein secretion and oncogenesis

Eimer, S, Audhya, A, Witte, K, Sarkeshik, A, Yates, JR, Schuh, AL, Mayers, JR, Hegermann, J, Schwarze, K

Nat. Cell Biol. 2011
22675024 Insights into structural and regulatory roles of Sec16 in COPII vesicle formation at ER exit sites

Sato, K, Yorimitsu, T

Mol. Biol. Cell 2012
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