CRYM reduces P2C to PPCA

Stable Identifier
R-HSA-5693347
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
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CRYM reduces P2C to PPCA
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The ketimine reductase mu-crystallin protein (CRYM) is a key enzyme in the pipecolate pathway, which is the main lysine degradation pathway in the brain. One substrate from the pipecolate pathway that can be reduced by CRYM is piperideine-2-carboxylate (P2C) to L-pipecolic acid (PPCA) (Hallen et al 2015). CRYM is also a thyroid hormone binding protein, able to bind and transport 3,5,3'-triiodo-L-thyronine (T3) into nuclei and regulate thyroid hormone-related gene expression (Cheng et al. 2007).

Literature References
PubMed ID Title Journal Year
25931162 Insights into Enzyme Catalysis and Thyroid Hormone Regulation of Cerebral Ketimine Reductase/μ-Crystallin Under Physiological Conditions

Hallen, A, Cooper, AJ, Jamie, JF, Karuso, P

Neurochem. Res. 2015
17242435 Crystal structure of human micro-crystallin complexed with NADPH

Cheng, Z, Sun, L, He, J, Gong, W

Protein Sci. 2007
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thiomorpholine-carboxylate dehydrogenase activity of CRYM [peroxisomal matrix]
Physical Entity
CRYM [peroxisomal matrix]
Activity
thiomorpholine-carboxylate dehydrogenase activity (0047127)
Orthologous Events
CRYM reduces P2C to PPCA (Bos taurus)
CRYM reduces P2C to PPCA (Canis familiaris)
CRYM reduces P2C to PPCA (Danio rerio)
CRYM reduces P2C to PPCA (Dictyostelium discoideum)
CRYM reduces P2C to PPCA (Drosophila melanogaster)
CRYM reduces P2C to PPCA (Gallus gallus)
CRYM reduces P2C to PPCA (Mus musculus)
CRYM reduces P2C to PPCA (Rattus norvegicus)
CRYM reduces P2C to PPCA (Saccharomyces cerevisiae)
CRYM reduces P2C to PPCA (Schizosaccharomyces pombe)
CRYM reduces P2C to PPCA (Sus scrofa)
CRYM reduces P2C to PPCA (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-05-15)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-15)