The ketimine reductase mu-crystallin protein (CRYM) is a key enzyme in the pipecolate pathway, which is the main lysine degradation pathway in the brain. One substrate from the pipecolate pathway that can be reduced by CRYM is piperideine-2-carboxylate (P2C) to L-pipecolic acid (PPCA) (Hallen et al 2015). CRYM is also a thyroid hormone binding protein, able to bind and transport 3,5,3'-triiodo-L-thyronine (T3) into nuclei and regulate thyroid hormone-related gene expression (Cheng et al. 2007).
Hallen, A, Cooper, AJ, Jamie, JF, Karuso, P
Cheng, Z, Sun, L, He, J, Gong, W
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