CRYM reduces P2C to PPCA

Stable Identifier
R-HSA-5693347
Type
Reaction
Species
Homo sapiens
Compartment
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The ketimine reductase mu-crystallin protein (CRYM) is a key enzyme in the pipecolate pathway, which is the main lysine degradation pathway in the brain. One substrate from the pipecolate pathway that can be reduced by CRYM is piperideine-2-carboxylate (P2C) to L-pipecolic acid (PPCA) (Hallen et al 2015). CRYM is also a thyroid hormone binding protein, able to bind and transport 3,5,3'-triiodo-L-thyronine (T3) into nuclei and regulate thyroid hormone-related gene expression (Cheng et al. 2007).

Literature References
PubMed ID Title Journal Year
17242435 Crystal structure of human micro-crystallin complexed with NADPH

Cheng, Z, Sun, L, Gong, W, He, J

Protein Sci. 2007
25931162 Insights into Enzyme Catalysis and Thyroid Hormone Regulation of Cerebral Ketimine Reductase/μ-Crystallin Under Physiological Conditions

Cooper, AJ, Karuso, P, Jamie, JF, Hallen, A

Neurochem. Res. 2015
Participants
Participates
Catalyst Activity

thiomorpholine-carboxylate dehydrogenase activity of CRYM [peroxisomal matrix]

Orthologous Events
Cross References
Rhea
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