Reactome | CRYM reduces P2C to PPCA

CRYM reduces P2C to PPCA

Stable Identifier

R-HSA-5693347

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

Delta(1)-piperideine-2-carboxylate + H(+) + NADPH => L-pipecolate + NADP(+)

ReviewStatus

5/5

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The ketimine reductase mu-crystallin protein (CRYM) is a key enzyme in the pipecolate pathway, which is the main lysine degradation pathway in the brain. One substrate from the pipecolate pathway that can be reduced by CRYM is piperideine-2-carboxylate (P2C) to L-pipecolic acid (PPCA) (Hallen et al 2015). CRYM is also a thyroid hormone binding protein, able to bind and transport 3,5,3'-triiodo-L-thyronine (T3) into nuclei and regulate thyroid hormone-related gene expression (Cheng et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17242435	Crystal structure of human micro-crystallin complexed with NADPH Cheng, Z, Sun, L, Gong, W, He, J	Protein Sci.	2007
25931162	Insights into Enzyme Catalysis and Thyroid Hormone Regulation of Cerebral Ketimine Reductase/μ-Crystallin Under Physiological Conditions Cooper, AJ, Karuso, P, Jamie, JF, Hallen, A	Neurochem. Res.	2015