Reactome | CRYM reduces P2C to PPCA

CRYM reduces P2C to PPCA

Stable Identifier

R-HSA-5693347

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

Delta(1)-piperideine-2-carboxylate + H(+) + NADPH => L-pipecolate + NADP(+)

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The ketimine reductase mu-crystallin protein (CRYM) is a key enzyme in the pipecolate pathway, which is the main lysine degradation pathway in the brain. One substrate from the pipecolate pathway that can be reduced by CRYM is piperideine-2-carboxylate (P2C) to L-pipecolic acid (PPCA) (Hallen et al 2015). CRYM is also a thyroid hormone binding protein, able to bind and transport 3,5,3'-triiodo-L-thyronine (T3) into nuclei and regulate thyroid hormone-related gene expression (Cheng et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17242435	Crystal structure of human micro-crystallin complexed with NADPH Cheng, Z, Sun, L, He, J, Gong, W	Protein Sci.	2007
25931162	Insights into Enzyme Catalysis and Thyroid Hormone Regulation of Cerebral Ketimine Reductase/μ-Crystallin Under Physiological Conditions Hallen, A, Cooper, AJ, Jamie, JF, Karuso, P	Neurochem. Res.	2015