Reactome | ASPA deacetylates NAASP to acetate and L-aspartate

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ASPA deacetylates NAASP to acetate and L-aspartate Show undefined attributes

authored	[InstanceEdit:5691505] Jassal, Bijay, 2015-05-08
catalystActivity	[CatalystActivity:5691509] aspartoacylase activity of ASPA:Zn2+ dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5691505] Jassal, Bijay, 2015-05-08
crossReference	[DatabaseIdentifier:12667530] RHEA:59409 [DatabaseIdentifier:9925768] RHEA:59409
dbId	5691507
displayName	ASPA deacetylates NAASP to acetate and L-aspartate
edited	[InstanceEdit:5691505] Jassal, Bijay, 2015-05-08
eventOf	[Pathway:R-HSA-8963693] Aspartate and asparagine metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-6787757] PXLP-K333-GADL1 decarboxylates acidic AAs - Homo sapiens [Reaction:R-HSA-70599] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS] - Homo sapiens [Reaction:R-HSA-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-5693772] NAASP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5691518] Identification of the zinc binding ligands and the catalytic residue in human aspartoacylase, an enzyme involved in Canavan disease [LiteratureReference:5692242] Characterization of human aspartoacylase: the brain enzyme responsible for Canavan disease [LiteratureReference:5692214] Structure of aspartoacylase, the brain enzyme impaired in Canavan disease
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ASPA deacetylates NAASP to acetate and L-aspartate H2O + N-acetyl-L-aspartate => acetate + L-aspartate
orthologousEvent	[Reaction:R-GGA-5691507] ASPA deacetylates NAASP to acetate and L-aspartate - Gallus gallus [Reaction:R-XTR-5691507] ASPA deacetylates NAASP to acetate and L-aspartate - Xenopus tropicalis [Reaction:R-DRE-5691507] ASPA deacetylates NAASP to acetate and L-aspartate - Danio rerio [Reaction:R-SSC-5691507] ASPA deacetylates NAASP to acetate and L-aspartate - Sus scrofa [Reaction:R-BTA-5691507] ASPA deacetylates NAASP to acetate and L-aspartate - Bos taurus [Reaction:R-CFA-5691507] ASPA deacetylates NAASP to acetate and L-aspartate - Canis familiaris [Reaction:R-RNO-5691507] ASPA deacetylates NAASP to acetate and L-aspartate - Rattus norvegicus [Reaction:R-MMU-5691507] ASPA deacetylates NAASP to acetate and L-aspartate - Mus musculus
output	[SimpleEntity:R-ALL-29416] CH3COO- [cytosol] [SimpleEntity:R-ALL-29448] L-Asp [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-8954513] NAASP translocates from mitochondrial matrix to cytosol - Homo sapiens [Reaction:R-HSA-5693783] NAALADases hydrolyse NAAG - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26 [InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5691507
summation	[Summation:5692244] Aspartoacylase (ASPA) is a cytosolic zinc metalloenzyme high...
updateTrackers	[UpdateTracker:9928400] Update Tracker - [Reaction:5691507] ASPA deacetylates NAASP to acetate and L-aspartate - v91:[add_removeInput]

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(updatedInstance)	[UpdateTracker:9928400] Update Tracker - [Reaction:5691507] ASPA deacetylates NAASP to acetate and L-aspartate - v91:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-8963693] Aspartate and asparagine metabolism
(precedingEvent)	[Reaction:R-HSA-6787757] PXLP-K333-GADL1 decarboxylates acidic AAs [Reaction:R-HSA-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp [Reaction:R-HSA-70599] aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]