CUL1, SKP1, FBXL5 bind

Stable Identifier
R-HSA-5691167
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CUL1, SKP1, FBXL5 bind
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of iron metabolism genes. The E3 ubiquitin ligase complex comprising the F-box/LRR-repeat protein 5 (FBXL5) protein, S-phase kinase-associated protein 1 (SKP1), cullin 1 (CUL1) and NEDD8. This complex targets iron-responsive element-binding protein 2 (IREB2) for proteasomal degradation in iron-replete cells (Vashisht et al. 2009, Salahudeen et al. 2009). Here, CUL1, FBXF5 and SKP1 bind.

Literature References
PubMed ID Title Journal Year
19762597 An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis

Salahudeen, AA, Thompson, JW, Ruiz, JC, Ma, HW, Kinch, LN, Li, Q, Grishin, NV, Bruick, RK

Science 2009
19762596 Control of iron homeostasis by an iron-regulated ubiquitin ligase

Vashisht, AA, Zumbrennen, KB, Huang, X, Powers, DN, Durazo, A, Sun, D, Bhaskaran, N, Persson, A, Uhlén, M, Sangfelt, O, Spruck, C, Leibold, EA, Wohlschlegel, JA

Science 2009
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
CUL1, SKP1, FBXL5 bind (Bos taurus)
CUL1, SKP1, FBXL5 bind (Canis familiaris)
CUL1, SKP1, FBXL5 bind (Danio rerio)
CUL1, SKP1, FBXL5 bind (Dictyostelium discoideum)
CUL1, SKP1, FBXL5 bind (Gallus gallus)
CUL1, SKP1, FBXL5 bind (Mus musculus)
CUL1, SKP1, FBXL5 bind (Rattus norvegicus)
CUL1, SKP1, FBXL5 bind (Saccharomyces cerevisiae)
CUL1, SKP1, FBXL5 bind (Sus scrofa)
CUL1, SKP1, FBXL5 bind (Xenopus tropicalis)
Authored
Jassal, B  (2015-05-05)
Reviewed
D'Eustachio, P  (2017-01-06)
Created
Jassal, B  (2015-05-05)