Cellular iron homeostasis is maintained by the coordinate posttranscriptional regulation of iron metabolism genes. The E3 ubiquitin ligase complex comprising the F-box/LRR-repeat protein 5 (FBXL5) protein, S-phase kinase-associated protein 1 (SKP1), cullin 1 (CUL1) and NEDD8. This complex targets iron-responsive element-binding protein 2 (IREB2) for proteasomal degradation in iron-replete cells (Vashisht et al. 2009, Salahudeen et al. 2009). Here, CUL1, FBXF5 and SKP1 bind.
Salahudeen, AA, Thompson, JW, Ruiz, JC, Ma, HW, Kinch, LN, Li, Q, Grishin, NV, Bruick, RK
Vashisht, AA, Zumbrennen, KB, Huang, X, Powers, DN, Durazo, A, Sun, D, Bhaskaran, N, Persson, A, Uhlén, M, Sangfelt, O, Spruck, C, Leibold, EA, Wohlschlegel, JA
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