Reactome | LYN phosphorylates CD22

Schema > Reaction > Entries

LYN phosphorylates CD22 Show undefined attributes

authored	[InstanceEdit:5690658] Garapati, Phani Vijay, 2015-04-30
catalystActivity	[CatalystActivity:983706] protein tyrosine kinase activity of MyrG2-PalmC3-LYN [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5690658] Garapati, Phani Vijay, 2015-04-30
dbId	5690702
displayName	LYN phosphorylates CD22
edited	[InstanceEdit:5690658] Garapati, Phani Vijay, 2015-04-30
eventOf	[Pathway:R-HSA-5690714] CD22 mediated BCR regulation - Homo sapiens
followingEvent	[Reaction:R-HSA-5690701] SHP1 binds p-CD22 - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-5690660] CD22:Antigen:p-BCR [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5690662] Inhibition of the B cell by CD22: a requirement for Lyn [LiteratureReference:5690724] Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes [LiteratureReference:5690705] A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	LYN phosphorylates CD22
orthologousEvent	[Reaction:R-SSC-5690702] LYN phosphorylates CD22 - Sus scrofa [Reaction:R-BTA-5690702] LYN phosphorylates CD22 - Bos taurus [Reaction:R-CFA-5690702] LYN phosphorylates CD22 - Canis familiaris [Reaction:R-RNO-5690702] LYN phosphorylates CD22 - Rattus norvegicus [Reaction:R-MMU-5690702] LYN phosphorylates CD22 - Mus musculus
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-5690689] p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane]
precedingEvent	[Reaction:R-HSA-5690740] CD22 binds B-cell receptor - Homo sapiens
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6809175] Paulson, James C, 2015-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5690702
summation	[Summation:5690738] After ligation of membrane-bound IgM, CD22 is quickly tyrosi...

Referrals

(precedingEvent)	[Reaction:R-HSA-5690701] SHP1 binds p-CD22
(hasEvent)	[Pathway:R-HSA-5690714] CD22 mediated BCR regulation

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