Reactome | CD22 binds B-cell receptor

Schema > Reaction > Entries

CD22 binds B-cell receptor Show undefined attributes

authored	[InstanceEdit:5690658] Garapati, Phani Vijay, 2015-04-30
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5690658] Garapati, Phani Vijay, 2015-04-30
dbId	5690740
displayName	CD22 binds B-cell receptor
edited	[InstanceEdit:5690658] Garapati, Phani Vijay, 2015-04-30
eventOf	[Pathway:R-HSA-5690714] CD22 mediated BCR regulation - Homo sapiens
followingEvent	[Reaction:R-HSA-5690702] LYN phosphorylates CD22 - Homo sapiens
input	[Complex:R-HSA-983691] Antigen:p-BCR [plasma membrane] [EntityWithAccessionedSequence:R-HSA-197703] CD22 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5690688] CD22 associates with the human surface IgM-B-cell antigen receptor complex [LiteratureReference:5690743] Binding of human plasma sialoglycoproteins by the B cell-specific lectin CD22. Selective recognition of immunoglobulin M and haptoglobin [LiteratureReference:5690695] Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling [LiteratureReference:5690668] Ig domains 1 and 2 of murine CD22 constitute the ligand-binding domain and bind multiple sialylated ligands expressed on B and T cells
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	CD22 binds B-cell receptor
orthologousEvent	[Reaction:R-SSC-5690740] CD22 binds B-cell receptor - Sus scrofa [Reaction:R-BTA-5690740] CD22 binds B-cell receptor - Bos taurus [Reaction:R-CFA-5690740] CD22 binds B-cell receptor - Canis familiaris [Reaction:R-RNO-5690740] CD22 binds B-cell receptor - Rattus norvegicus [Reaction:R-MMU-5690740] CD22 binds B-cell receptor - Mus musculus
output	[Complex:R-HSA-5690660] CD22:Antigen:p-BCR [plasma membrane]
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6809175] Paulson, James C, 2015-11-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5690740
summation	[Summation:5690678] Physical association of CD22 with the BCR seems to have dire...
updateTrackers	[UpdateTracker:9782370] Update Tracker - [Reaction:5690740] CD22 binds B-cell receptor - v59:[add_removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9782370] Update Tracker - [Reaction:5690740] CD22 binds B-cell receptor - v59:[add_removeLiteratureReference]
(precedingEvent)	[Reaction:R-HSA-5690702] LYN phosphorylates CD22
(hasEvent)	[Pathway:R-HSA-5690714] CD22 mediated BCR regulation