LYN phosphorylates CD22

Stable Identifier
R-HSA-5690702
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After ligation of membrane-bound IgM, CD22 is quickly tyrosine phosphorylated on its cytoplasmic ITIM sequence (immunoreceptor tyrosine-based inhibition motif). The tyrosine kinase involved in CD22 phosphorylation is LYN, a member of the Src kinase family (Smith et al. 1998). The CD22 cytoplasmic tail contains six tyrosines, three of which belong to the ITIM sequence (Nitschke & Tsubata 2004).

Literature References
PubMed ID Title Journal Year
9601638 Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes

Chan, VW, Lowell, CA, DeFranco, AL

Curr. Biol. 1998
9547345 A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals

Nishizumi, H, Horikawa, K, Mlinaric-Rascan, I, Yamamoto, T

J. Exp. Med. 1998
9480991 Inhibition of the B cell by CD22: a requirement for Lyn

Smith, KG, Tarlinton, DM, Doody, GM, Hibbs, ML, Fearon, DT

J. Exp. Med. 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of MyrG2-PalmC3-LYN [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created