Reactome | LYN phosphorylates CD22

LYN phosphorylates CD22

Stable Identifier

R-HSA-5690702

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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After ligation of membrane-bound IgM, CD22 is quickly tyrosine phosphorylated on its cytoplasmic ITIM sequence (immunoreceptor tyrosine-based inhibition motif). The tyrosine kinase involved in CD22 phosphorylation is LYN, a member of the Src kinase family (Smith et al. 1998). The CD22 cytoplasmic tail contains six tyrosines, three of which belong to the ITIM sequence (Nitschke & Tsubata 2004).

Literature References

PubMed ID	Title	Journal	Year
9547345	A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals Yamamoto, T, Nishizumi, H, Mlinaric-Rascan, I, Horikawa, K	J. Exp. Med.	1998
9601638	Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes Chan, VW, DeFranco, AL, Lowell, CA	Curr. Biol.	1998
9480991	Inhibition of the B cell by CD22: a requirement for Lyn Tarlinton, DM, Doody, GM, Hibbs, ML, Fearon, DT, Smith, KG	J. Exp. Med.	1998