LYN phosphorylates CD22

Stable Identifier
R-HSA-5690702
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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LYN phosphorylates CD22
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After ligation of membrane-bound IgM, CD22 is quickly tyrosine phosphorylated on its cytoplasmic ITIM sequence (immunoreceptor tyrosine-based inhibition motif). The tyrosine kinase involved in CD22 phosphorylation is LYN, a member of the Src kinase family (Smith et al. 1998). The CD22 cytoplasmic tail contains six tyrosines, three of which belong to the ITIM sequence (Nitschke & Tsubata 2004).

Literature References
PubMed ID Title Journal Year
9601638 Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes

Chan, VW, Lowell, CA, DeFranco, AL

Curr. Biol. 1998
9547345 A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals

Nishizumi, H, Horikawa, K, Mlinaric-Rascan, I, Yamamoto, T

J. Exp. Med. 1998
9480991 Inhibition of the B cell by CD22: a requirement for Lyn

Smith, KG, Tarlinton, DM, Doody, GM, Hibbs, ML, Fearon, DT

J. Exp. Med. 1998
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of MyrG2-PalmC3-LYN [plasma membrane]
Physical Entity
MyrG2-PalmC3-LYN [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
LYN phosphorylates CD22 (Canis familiaris)
LYN phosphorylates CD22 (Mus musculus)
LYN phosphorylates CD22 (Rattus norvegicus)
LYN phosphorylates CD22 (Sus scrofa)
LYN phosphorylates CD22 (Xenopus tropicalis)
Authored
Garapati, P V  (2015-04-30)
Reviewed
Paulson, JC  (2015-11-09)
Created
Garapati, P V  (2015-04-30)