After ligation of membrane-bound IgM, CD22 is quickly tyrosine phosphorylated on its cytoplasmic ITIM sequence (immunoreceptor tyrosine-based inhibition motif). The tyrosine kinase involved in CD22 phosphorylation is LYN, a member of the Src kinase family (Smith et al. 1998). The CD22 cytoplasmic tail contains six tyrosines, three of which belong to the ITIM sequence (Nitschke & Tsubata 2004).
Yamamoto, T, Nishizumi, H, Mlinaric-Rascan, I, Horikawa, K
Chan, VW, DeFranco, AL, Lowell, CA
Tarlinton, DM, Doody, GM, Hibbs, ML, Fearon, DT, Smith, KG
protein tyrosine kinase activity of MyrG2-PalmC3-LYN [plasma membrane]
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