LYN phosphorylates CD22

Stable Identifier
R-HSA-5690702
Type
Reaction
Species
Homo sapiens
Compartment
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After ligation of membrane-bound IgM, CD22 is quickly tyrosine phosphorylated on its cytoplasmic ITIM sequence (immunoreceptor tyrosine-based inhibition motif). The tyrosine kinase involved in CD22 phosphorylation is LYN, a member of the Src kinase family (Smith et al. 1998). The CD22 cytoplasmic tail contains six tyrosines, three of which belong to the ITIM sequence (Nitschke & Tsubata 2004).

Literature References
PubMed ID Title Journal Year
9547345 A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals

Yamamoto, T, Nishizumi, H, Mlinaric-Rascan, I, Horikawa, K

J. Exp. Med. 1998
9601638 Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes

Chan, VW, DeFranco, AL, Lowell, CA

Curr. Biol. 1998
9480991 Inhibition of the B cell by CD22: a requirement for Lyn

Tarlinton, DM, Doody, GM, Hibbs, ML, Fearon, DT, Smith, KG

J. Exp. Med. 1998
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of MyrG2-PalmC3-LYN [plasma membrane]

Orthologous Events
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