Reactome | ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA

Schema > Reaction > Entries

ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA Show undefined attributes

authored	[InstanceEdit:5690061] Jassal, Bijay, 2015-04-27
catalystActivity	[CatalystActivity:5690041] fatty acyl-CoA hydrolase activity of ACOT2,9, THEM4,5 dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:5690061] Jassal, Bijay, 2015-04-27
crossReference	[DatabaseIdentifier:9978276] RHEA:68185 [DatabaseIdentifier:9914126] RHEA:67681
dbId	5690066
displayName	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA
edited	[InstanceEdit:5690061] Jassal, Bijay, 2015-04-27
eventOf	[Pathway:R-HSA-77289] Mitochondrial Fatty Acid Beta-Oxidation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:8047] acyl-CoA metabolic process
input	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [DefinedSet:R-ALL-5690540] MCFA-CoA, LCFA-CoA [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5690372] New players on the metabolic stage: How do you like Them Acots? [LiteratureReference:5690404] The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism [LiteratureReference:5690417] Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs [LiteratureReference:5690551] Correlation of structure and function in the human hotdog-fold enzyme hTHEM4 [LiteratureReference:5690397] Functional and structural properties of mammalian acyl-coenzyme A thioesterases [LiteratureReference:5690436] Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA a medium-chain fatty acyl-CoA + H2O => a medium-chain fatty acid + CoA + H(+) a long-chain fatty acyl-CoA + H2O => a long-chain fatty acid + CoA + H(+)
orthologousEvent	[Reaction:R-CFA-5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA - Canis familiaris [Reaction:R-PFA-5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA - Plasmodium falciparum [Reaction:R-DDI-5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA - Dictyostelium discoideum [Reaction:R-CEL-5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA - Caenorhabditis elegans [Reaction:R-DME-5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA - Drosophila melanogaster [Reaction:R-GGA-5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA - Gallus gallus [Reaction:R-XTR-5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA - Xenopus tropicalis [Reaction:R-DRE-5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA - Danio rerio [Reaction:R-SSC-5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA - Sus scrofa [Reaction:R-BTA-5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA - Bos taurus [Reaction:R-RNO-5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA - Rattus norvegicus [Reaction:R-MMU-5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA - Mus musculus
output	[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [DefinedSet:R-ALL-5690519] MCFA, LCFA [mitochondrial matrix]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-09-22
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26 [InstanceEdit:9978314] D'Eustachio, Peter, 2025-12-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5690066
summation	[Summation:5690546] The maintenance/regulation of cellular levels of free fatty ...
updateTrackers	[UpdateTracker:9984605] Update Tracker - [Reaction:5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA - v96:[removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9984605] Update Tracker - [Reaction:5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA - v96:[removeOutput]
(hasEvent)	[Pathway:R-HSA-77289] Mitochondrial Fatty Acid Beta-Oxidation