Reactome | ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA

Schema > Reaction > Entries

ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10295711] fatty acyl-CoA hydrolase activity of ACOT2,9, THEM4,5 dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10295713
displayName	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA
eventOf	[Pathway:R-CFA-77289] Mitochondrial Fatty Acid Beta-Oxidation - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8047] acyl-CoA metabolic process
inferredFrom	[Reaction:R-HSA-5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [DefinedSet:R-ALL-5690540] MCFA-CoA, LCFA-CoA [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA a medium-chain fatty acyl-CoA + H2O => a medium-chain fatty acid + CoA + H(+) a long-chain fatty acyl-CoA + H2O => a long-chain fatty acid + CoA + H(+)
output	[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [DefinedSet:R-ALL-5690519] MCFA, LCFA [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5690066
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-77289] Mitochondrial Fatty Acid Beta-Oxidation
(inferredTo)	[Reaction:R-HSA-5690066] ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA

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