Reactome | ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA

ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA

Stable Identifier

R-HSA-5690066

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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ACOT2,9,THEM4,5 hydrolyse MCFA-CoA, LCFA-CoA

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The maintenance/regulation of cellular levels of free fatty acids and fatty acyl-CoAs (the activated form of free fatty acids) is extremely important, as imbalances in lipid metabolism can have serious consequences for human health. Acyl-coenzyme A thioesterases (ACOTs) hydrolyse the thioester bond in medium- to long-chain fatty acyl-CoAs (of C12-C18 lengths) (MCFA-CoA, LCFA-CoA) to their free fatty acids (MCFA, LCFA) (Cohen 2013, Hunt et al. 2012, Kirkby et al. 2010). ACOTs that function in the mitochondrion are ACOT2 (Hunt et al. 2006), ACOT9 (Kirkby et al. 2010), THEM4 dimer (Zhuravleva et al. 2012, Zhao et al. 2012) and THEM5 dimer (Zhuravleva et al. 2012). THEM4 is also functional in the cytosol and at the plasma membrane (Cohen 2013).

Literature References

PubMed ID	Title	Journal	Year
20470824	Functional and structural properties of mammalian acyl-coenzyme A thioesterases Forwood, JK, Kobe, B, Roman, N, Kirkby, B, Kellie, S	Prog. Lipid Res.	2010
16940157	Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs Westin, MA, Alexson, SE, Svensson, LT, Rautanen, A, Hunt, MC	FASEB J.	2006
22586271	Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development Dummler, B, Zhuravleva, E, Marcellin, D, Gut, H, Esposti, MD, Cron, P, Bleck, CK, Hynx, D, Keusch, JJ, Genoud, C, Hemmings, BA	Mol. Cell. Biol.	2012
22465940	The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism Alexson, SE, Siponen, MI, Hunt, MC	Biochim. Biophys. Acta	2012
23700546	New players on the metabolic stage: How do you like Them Acots? Cohen, DE	Adipocyte	2013
22871024	Correlation of structure and function in the human hotdog-fold enzyme hTHEM4 Lim, K, Pathak, MC, Herzberg, O, Luo, L, Latham, JA, Choudry, A, Zhao, H, Dunaway-Mariano, D, Dominguez, D	Biochemistry	2012