Reactome | p-S MAPK6,4 phosphorylate MAPKAPK5

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p-S MAPK6,4 phosphorylate MAPKAPK5 Show undefined attributes

authored	[InstanceEdit:5685867] Rothfels, Karen, 2015-03-30
catalystActivity	[CatalystActivity:5687072] protein serine/threonine kinase activity of p-S MAPK6,4:MAKPAPK5 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5687093] Rothfels, Karen, 2015-04-06
dbId	5687094
displayName	p-S MAPK6,4 phosphorylate MAPKAPK5
edited	[InstanceEdit:5692861] Rothfels, Karen, 2015-05-13
eventOf	[Pathway:R-HSA-5687128] MAPK6/MAPK4 signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-5687120] p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-5687063] p-S MAPK6,4:MAKPAPK5 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5686762] Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5 [LiteratureReference:5686841] Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4 [LiteratureReference:5686782] Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif [LiteratureReference:5686768] Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway [LiteratureReference:5686851] The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5 [LiteratureReference:5690220] Scaffolding by ERK3 regulates MK5 in development [LiteratureReference:5686777] Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	p-S MAPK6,4 phosphorylate MAPKAPK5
orthologousEvent	[Reaction:R-GGA-5687094] p-S MAPK6,4 phosphorylate MAPKAPK5 - Gallus gallus [Reaction:R-DRE-5687094] p-S MAPK6,4 phosphorylate MAPKAPK5 - Danio rerio [Reaction:R-SSC-5687094] p-S MAPK6,4 phosphorylate MAPKAPK5 - Sus scrofa [Reaction:R-BTA-5687094] p-S MAPK6,4 phosphorylate MAPKAPK5 - Bos taurus [Reaction:R-RNO-5687094] p-S MAPK6,4 phosphorylate MAPKAPK5 - Rattus norvegicus [Reaction:R-MMU-5687094] p-S MAPK6,4 phosphorylate MAPKAPK5 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-5687062] p-S MAPK6,4:p-T182 MAKPAPK5 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5687091] p-S MAPK6,4 binds MAPKAPK5 - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690232] Moens, Ugo, 2015-04-24 [InstanceEdit:5691290] Seternes, Ole-Morten, 2015-05-05 [InstanceEdit:5692746] Mathien, Simon, 2015-05-12 [InstanceEdit:5692748] Meloche, Sylvain, 2015-05-12 [InstanceEdit:5692747] Soulez, Mathilde, 2015-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5687094
summation	[Summation:5686872] Activated MAPK6 and MAPK4 promote the phosphorylation of MAP...

Referrals

(hasEvent)	[Pathway:R-HSA-5687128] MAPK6/MAPK4 signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-5687120] p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol

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