Reactome | p-S MAPK6,4 phosphorylate MAPKAPK5

Schema > Reaction > Entries

p-S MAPK6,4 phosphorylate MAPKAPK5 Show undefined attributes

catalystActivity	[CatalystActivity:10795246] protein serine/threonine kinase activity of p-S MAPK6,4:MAKPAPK5 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10795248
displayName	p-S MAPK6,4 phosphorylate MAPKAPK5
eventOf	[Pathway:R-GGA-5687128] MAPK6/MAPK4 signaling - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-GGA-5687120] p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol - Gallus gallus
inferredFrom	[Reaction:R-HSA-5687094] p-S MAPK6,4 phosphorylate MAPKAPK5 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-GGA-5687063] p-S MAPK6,4:MAKPAPK5 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	p-S MAPK6,4 phosphorylate MAPKAPK5
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-GGA-5687062] p-S MAPK6,4:p-T182 MAKPAPK5 [nucleoplasm]
precedingEvent	[Reaction:R-GGA-5687091] p-S MAPK6,4 binds MAPKAPK5 - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-5687094
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-5687128] MAPK6/MAPK4 signaling
(precedingEvent)	[BlackBoxEvent:R-GGA-5687120] p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol
(inferredTo)	[Reaction:R-HSA-5687094] p-S MAPK6,4 phosphorylate MAPKAPK5

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