Reactome | p-S MAPK6,4 binds MAPKAPK5

Schema > Reaction > Entries

p-S MAPK6,4 binds MAPKAPK5 Show undefined attributes

authored	[InstanceEdit:5685867] Rothfels, Karen, 2015-03-30
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5687092] Rothfels, Karen, 2015-04-06
dbId	5687091
displayName	p-S MAPK6,4 binds MAPKAPK5
edited	[InstanceEdit:5692861] Rothfels, Karen, 2015-05-13
eventOf	[Pathway:R-HSA-5687128] MAPK6/MAPK4 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-5687094] p-S MAPK6,4 phosphorylate MAPKAPK5 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2562517] MAPKAPK5 [nucleoplasm] [DefinedSet:R-HSA-5687052] p-S MAPK6,4 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5686782] Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif [LiteratureReference:5686851] The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5 [LiteratureReference:5686841] Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4 [LiteratureReference:5686768] Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway [LiteratureReference:5686762] Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	p-S MAPK6,4 binds MAPKAPK5
orthologousEvent	[Reaction:R-GGA-5687091] p-S MAPK6,4 binds MAPKAPK5 - Gallus gallus [Reaction:R-DRE-5687091] p-S MAPK6,4 binds MAPKAPK5 - Danio rerio [Reaction:R-SSC-5687091] p-S MAPK6,4 binds MAPKAPK5 - Sus scrofa [Reaction:R-BTA-5687091] p-S MAPK6,4 binds MAPKAPK5 - Bos taurus [Reaction:R-RNO-5687091] p-S MAPK6,4 binds MAPKAPK5 - Rattus norvegicus [Reaction:R-MMU-5687091] p-S MAPK6,4 binds MAPKAPK5 - Mus musculus
output	[Complex:R-HSA-5687063] p-S MAPK6,4:MAKPAPK5 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-5687107] MAPK4,6 translocate to nucleus - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690232] Moens, Ugo, 2015-04-24 [InstanceEdit:5691290] Seternes, Ole-Morten, 2015-05-05 [InstanceEdit:5692746] Mathien, Simon, 2015-05-12 [InstanceEdit:5692748] Meloche, Sylvain, 2015-05-12 [InstanceEdit:5692747] Soulez, Mathilde, 2015-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5687091
summation	[Summation:5686870] In proliferating cells, p-S189 MAPK6 and pS-186 MAPK4 bind t...

Referrals

(hasEvent)	[Pathway:R-HSA-5687128] MAPK6/MAPK4 signaling
(precedingEvent)	[Reaction:R-HSA-5687094] p-S MAPK6,4 phosphorylate MAPKAPK5