In proliferating cells, p-S189 MAPK6 and pS-186 MAPK4 bind to the MAPK effector kinase MAPKAPK5 (also known as MK5) through an FRIEDE motif in the C-terminal region (Perander et al, 2008; Deleris et al, 2008; Aberg et al, 2009). This motif, which is unique to MAPK6 and MAPK4 binds to the C-terminal 50 residues of MAPKAKP5 and is required for both the cytoplasmic accumulation and the activation of MAPKAPK5 (Aberg et al, 2009; Aberg et al, 2006; Seternes et al, 2004; Deleris et al, 2008). Cytoplasmic redistribution of MAPKAPK5 depends on the protein-protein interaction with MAPK6 or 4 and not the activity of any of the kinases, as cytoplasmic localization is abrogated by disruption of the interaction interface but not by kinase-dead versions of MAPK6, 4 or MAPKAPK5 itself (Aberg et al, 2006; Seternes et al, 2004).
Meloche, S, Julien, C, Johansen, B, Aberg, E, Keyse, SM, Perander, M, Seternes, OM
Déléris, P, Rousseau, J, Meloche, S, Rodier, G, Coulombe, P, Tanguay, PL
Johansen, B, Aberg, E, Torgersen, KM, Perander, M, Keyse, SM, Seternes, OM
Meloche, S, Johansen, B, Morrice, NA, Mikalsen, T, Moens, U, Armstrong, CG, Keyse, SM, Turgeon, B, Michaelsen, E, Seternes, OM
Johansen, B, Aberg, E, Keyse, SM, Perander, M, Dreyer, B, Guldvik, IJ, Seternes, OM, Outzen, H
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