Reactome | p-S MAPK6 phosphorylates NCOA3

Schema > Reaction > Entries

p-S MAPK6 phosphorylates NCOA3 Show undefined attributes

authored	[InstanceEdit:5686894] Rothfels, Karen, 2015-04-02
catalystActivity	[CatalystActivity:5687076] protein serine/threonine kinase activity of p-S189 MAPK6 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5687089] Rothfels, Karen, 2015-04-06
dbId	5687090
displayName	p-S MAPK6 phosphorylates NCOA3
edited	[InstanceEdit:5692861] Rothfels, Karen, 2015-05-13
eventOf	[Pathway:R-HSA-5687128] MAPK6/MAPK4 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-5687097] p-S857 NCOA3 binds ETV4 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-442488] NCOA3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5686969] ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion [LiteratureReference:5686944] The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression [LiteratureReference:5686953] Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression [LiteratureReference:5686958] Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression [LiteratureReference:5686857] Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	p-S MAPK6 phosphorylates NCOA3
orthologousEvent	[Reaction:R-GGA-5687090] p-S MAPK6 phosphorylates NCOA3 - Gallus gallus [Reaction:R-XTR-5687090] p-S MAPK6 phosphorylates NCOA3 - Xenopus tropicalis [Reaction:R-SSC-5687090] p-S MAPK6 phosphorylates NCOA3 - Sus scrofa [Reaction:R-BTA-5687090] p-S MAPK6 phosphorylates NCOA3 - Bos taurus [Reaction:R-CFA-5687090] p-S MAPK6 phosphorylates NCOA3 - Canis familiaris [Reaction:R-RNO-5687090] p-S MAPK6 phosphorylates NCOA3 - Rattus norvegicus [Reaction:R-MMU-5687090] p-S MAPK6 phosphorylates NCOA3 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5687005] p-S857 NCOA3 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-5687107] MAPK4,6 translocate to nucleus - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690232] Moens, Ugo, 2015-04-24 [InstanceEdit:5691290] Seternes, Ole-Morten, 2015-05-05 [InstanceEdit:5692746] Mathien, Simon, 2015-05-12 [InstanceEdit:5692748] Meloche, Sylvain, 2015-05-12 [InstanceEdit:5692747] Soulez, Mathilde, 2015-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5687090
summation	[Summation:5686997] MAPK6 is proposed to phosphorylate NCOA3 at serine 857. Thi...

Referrals

(precedingEvent)	[Reaction:R-HSA-5687097] p-S857 NCOA3 binds ETV4
(hasEvent)	[Pathway:R-HSA-5687128] MAPK6/MAPK4 signaling