Reactome | DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs

Schema > Reaction > Entries

DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5686926] Orlic-Milacic, Marija, 2015-04-06
dbId	5686924
displayName	DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693571] Nonhomologous End-Joining (NHEJ) - Homo sapiens
followingEvent	[Reaction:R-HSA-5687183] PRKDC phosphorylates DCLRE1C at DNA DSBs - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5686708] p-S645-DCLRE1C [nucleoplasm] [Complex:R-HSA-5687154] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:DNA DSB ends [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:76272] Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. [LiteratureReference:76305] Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair.
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs
orthologousEvent	[Reaction:R-GGA-5686924] DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs - Gallus gallus [Reaction:R-DRE-5686924] DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs - Danio rerio [Reaction:R-SSC-5686924] DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs - Sus scrofa [Reaction:R-BTA-5686924] DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs - Bos taurus [Reaction:R-CFA-5686924] DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs - Canis familiaris [Reaction:R-RNO-5686924] DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs - Rattus norvegicus [Reaction:R-MMU-5686924] DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs - Mus musculus
output	[Complex:R-HSA-5686925] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S645-DCLRE1C:DNA DSB ends [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5686704] Activated ATM phosphorylates DCLRE1C - Homo sapiens [Reaction:R-HSA-5693575] DNA-PKcs autophosphorylates - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5686924
summation	[Summation:5687156] DCLRE1C (ARTEMIS) forms a stable complex with PRKDC (DNA-PKc...

Referrals

(hasEvent)	[Pathway:R-HSA-5693571] Nonhomologous End-Joining (NHEJ)
(precedingEvent)	[Reaction:R-HSA-5687183] PRKDC phosphorylates DCLRE1C at DNA DSBs