Reactome | DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs

Schema > Reaction > Entries

DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10520378
displayName	DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs
eventOf	[Pathway:R-SSC-5693571] Nonhomologous End-Joining (NHEJ) - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-5687183] PRKDC phosphorylates DCLRE1C at DNA DSBs - Sus scrofa
inferredFrom	[Reaction:R-HSA-5686924] DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs - Homo sapiens
input	[Complex:R-SSC-5687154] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:DNA DSB ends [nucleoplasm] [EntityWithAccessionedSequence:R-SSC-5686708] phospho-DCLRE1C [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs
output	[Complex:R-SSC-5686925] p-T2609,S2612,T2638,T2647-PRKDC:XRCC5:XRCC6:p-S645-DCLRE1C:DNA DSB ends [nucleoplasm]
precedingEvent	[Reaction:R-SSC-5686704] Activated ATM phosphorylates DCLRE1C - Sus scrofa [Reaction:R-SSC-5693575] DNA-PKcs autophosphorylates - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5686924
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-5693571] Nonhomologous End-Joining (NHEJ)
(precedingEvent)	[Reaction:R-SSC-5687183] PRKDC phosphorylates DCLRE1C at DNA DSBs
(inferredTo)	[Reaction:R-HSA-5686924] DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs

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