Reactome | DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs

DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs

Stable Identifier

R-HSA-5686924

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs

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DCLRE1C (ARTEMIS) forms a stable complex with PRKDC (DNA-PKcs), even in the absence of DNA ends (Ma et al. 2002). Autophosphorylation of PRKDC as well as ATM-mediated phosphorylation of DCLRE1C are not prerequisites for the interaction of PRKDC and DCLRE1C (Ding et al.2003).

Literature References

PubMed ID	Title	Journal	Year
11955432	Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Ma, Y, Pannicke, U, Schwarz, K, Lieber, MR	Cell	2002
12897153	Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Ding, Q, Reddy, YV, Wang, W, Woods, T, Douglas, P, Ramsden, DA, Lees-Miller, SP, Meek, K	Mol Cell Biol	2003