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Entries
SHC-related events triggered by IGF1R
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authored
[InstanceEdit:2428925] May, B, 2012-08-06
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:2428929] May, B, 2012-08-08
crossReference
[DatabaseIdentifier:12325476] BioModels Database:BIOMD0000000466
[DatabaseIdentifier:12325402] BioModels Database:BIOMD0000000940
[DatabaseIdentifier:12325480] BioModels Database:BIOMD0000000468
[DatabaseIdentifier:12325446] BioModels Database:BIOMD0000000424
dbId
2428933
displayName
SHC-related events triggered by IGF1R
edited
[InstanceEdit:2428925] May, B, 2012-08-06
eventOf
[Pathway:R-HSA-2428924] IGF1R signaling cascade - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-2404195] IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 - Homo sapiens
[Reaction:R-HSA-2404193] IGF1R phosphorylates SHC1 - Homo sapiens
[Reaction:R-HSA-5686072] p-3Y-SHC1 dissociates from IGF1R - Homo sapiens
[Reaction:R-HSA-5686073] GRB2-1:SOS1 binds p-3Y-SHC1 - Homo sapiens
[Reaction:R-HSA-5686318] GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:2454001] Biological & physiological aspects of action of insulin-like growth factor peptide family
[LiteratureReference:2454014] Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain
[LiteratureReference:2454041] Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances
[LiteratureReference:2454045] Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer
[LiteratureReference:2454004] The type 1 insulin-like growth factor receptor pathway
modified
[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name
SHC-related events triggered by IGF1R
orthologousEvent
[Pathway:R-MMU-2428933] SHC-related events triggered by IGF1R - Mus musculus
[Pathway:R-DME-2428933] SHC-related events triggered by IGF1R - Drosophila melanogaster
[Pathway:R-GGA-2428933] SHC-related events triggered by IGF1R - Gallus gallus
[Pathway:R-XTR-2428933] SHC-related events triggered by IGF1R - Xenopus tropicalis
[Pathway:R-SSC-2428933] SHC-related events triggered by IGF1R - Sus scrofa
[Pathway:R-BTA-2428933] SHC-related events triggered by IGF1R - Bos taurus
[Pathway:R-CFA-2428933] SHC-related events triggered by IGF1R - Canis familiaris
[Pathway:R-RNO-2428933] SHC-related events triggered by IGF1R - Rattus norvegicus
releaseDate
2012-12-04
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2566980] Holzenberger, Martin, 2012-11-09
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-2428933
summation
[Summation:2454002] Phosphorylated IGF1R binds and phosphorylates SHC1 (reviewed...
Referrals
(hasEvent)
[Pathway:R-HSA-2428924] IGF1R signaling cascade
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