Reactome | ATM phosphorylates RBBP8

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ATM phosphorylates RBBP8 Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5684141] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5684136] Orlic-Milacic, Marija, 2015-03-19
dbId	5684140
displayName	ATM phosphorylates RBBP8
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends - Homo sapiens
followingEvent	[Reaction:R-HSA-5684108] BRCA1 binds phosphorylated RBBP8 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-5684095] DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5684148] The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	ATM phosphorylates RBBP8
orthologousEvent	[Reaction:R-MMU-5684140] ATM phosphorylates RBBP8 - Mus musculus [Reaction:R-DME-5684140] ATM phosphorylates RBBP8 - Drosophila melanogaster [Reaction:R-GGA-5684140] ATM phosphorylates RBBP8 - Gallus gallus [Reaction:R-DRE-5684140] ATM phosphorylates RBBP8 - Danio rerio [Reaction:R-SSC-5684140] ATM phosphorylates RBBP8 - Sus scrofa [Reaction:R-BTA-5684140] ATM phosphorylates RBBP8 - Bos taurus [Reaction:R-CFA-5684140] ATM phosphorylates RBBP8 - Canis familiaris [Reaction:R-RNO-5684140] ATM phosphorylates RBBP8 - Rattus norvegicus
output	4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-5684135] DNA DSBs:p-MRN:p-S327,T847,T859-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5684096] CDK2 phosphorylates RBBP8 - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5684140
summation	[Summation:5684142] CDK2-mediated phosphorylation of RBBP8 (CtIP) triggers ATM-m...
updateTrackers	[UpdateTracker:9775809] Update Tracker - [Reaction:5684140] ATM phosphorylates RBBP8 - v78:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775809] Update Tracker - [Reaction:5684140] ATM phosphorylates RBBP8 - v78:[modifyText]
(hasEvent)	[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends
(precedingEvent)	[Reaction:R-HSA-5684108] BRCA1 binds phosphorylated RBBP8