Reactome | CDK2 phosphorylates RBBP8

Schema > Reaction > Entries

CDK2 phosphorylates RBBP8 Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5684098] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5684101] Orlic-Milacic, Marija, 2015-03-19
dbId	5684096
displayName	CDK2 phosphorylates RBBP8
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends - Homo sapiens
followingEvent	[Reaction:R-HSA-5684140] ATM phosphorylates RBBP8 - Homo sapiens
input	8 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-5684094] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5684082] Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2
modified	[InstanceEdit:10871105] Wright, Adam, 2024-03-08
name	CDK2 phosphorylates RBBP8
orthologousEvent	[Reaction:R-MMU-5684096] CDK2 phosphorylates RBBP8 - Mus musculus [Reaction:R-SPO-5684096] CDK2 phosphorylates RBBP8 - Schizosaccharomyces pombe [Reaction:R-DME-5684096] CDK2 phosphorylates RBBP8 - Drosophila melanogaster [Reaction:R-GGA-5684096] CDK2 phosphorylates RBBP8 - Gallus gallus [Reaction:R-SSC-5684096] CDK2 phosphorylates RBBP8 - Sus scrofa [Reaction:R-BTA-5684096] CDK2 phosphorylates RBBP8 - Bos taurus [Reaction:R-CFA-5684096] CDK2 phosphorylates RBBP8 - Canis familiaris [Reaction:R-RNO-5684096] CDK2 phosphorylates RBBP8 - Rattus norvegicus
output	8 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-187952] CCNA:p-T160-CDK2 [nucleoplasm] [Complex:R-HSA-5684095] DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5684081] MRN complex binds CDK2 and RBBP8 - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5684096
summation	[Summation:5684103] CDK2, in complex with cyclin A (CCNA), phosphorylates RBBP8 ...

Referrals

(hasEvent)	[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends
(precedingEvent)	[Reaction:R-HSA-5684140] ATM phosphorylates RBBP8 [NegativePrecedingEvent:9766961] Futile Cycle: CDK2 phosphorylates RBBP8