Reactome | Activated MAPKs phosphorylate MAP2K1

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Activated MAPKs phosphorylate MAP2K1 Show undefined attributes

catalystActivity	[CatalystActivity:10881504] protein serine/threonine kinase activity of p-T,Y MAPK monomers and dimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10881506
displayName	Activated MAPKs phosphorylate MAP2K1
eventOf	[Pathway:R-DME-5674499] Negative feedback regulation of MAPK pathway - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5674496] Activated MAPKs phosphorylate MAP2K1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-DME-5672705] p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated MAPKs phosphorylate MAP2K1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DME-5674489] p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5674496
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5674499] Negative feedback regulation of MAPK pathway
(inferredTo)	[Reaction:R-HSA-5674496] Activated MAPKs phosphorylate MAP2K1

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