Activated MAPKs phosphorylate MAP2K1

Stable Identifier
R-HSA-5674496
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated MAPK proteins negatively regulate MAP2K1:MAP2K2 heterodimers by phosphorylating MAP2K1 at T292, a residue that is not present in MAP2K2. Phosphorylation of this site in MAP2K1 promotes the dephosphorylation of the MAP2K phosphorylated activation loop (AL) by an unknown mechanism, establishing a negative feedback loop that limits MAPK signaling (Catalanotti et al, 2009; Brunet et al, 1994; Xu et al, 1999). Deletion of MAP2K1 or mutation of this site prolongs MAP2K2 AL phosphorylation and MAPK activation (Catalanotti et al, 2009).

Literature References
PubMed ID Title Journal Year
10567369 The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo

Xu, BE, Wilsbacher, JL, Collisson, T, Cobb, MH

J. Biol. Chem. 1999
19219045 A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal

Catalanotti, F, Reyes, G, Jesenberger, V, Galabova-Kovacs, G, de Matos Simoes, R, Carugo, O, Baccarini, M

Nat. Struct. Mol. Biol. 2009
8013650 Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1)

Brunet, A, Pages, G, Pouyssegur, J

FEBS Lett 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,Y MAPK monomers and dimers [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created