Reactome | YWHAB dimer dissociates from KSR1:MARK3

YWHAB dimer dissociates from KSR1:MARK3

Stable Identifier

R-HSA-5672958

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

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Dephosphorylation of KSR1 S406 by PP2A promotes the dissociation of 14-3-3 from this site, exposing both the CR1 region that is required for membrane localization of KSR1 and the MAPK-binding FxFP motif (Ory et al, 2003; Muller et al, 2001; reviewed in Raabe and Raap, 2003).

Literature References

PubMed ID	Title	Journal	Year
12932339	Ras signaling: PP2A puts Ksr and Raf in the right place Raabe, T, Rapp, UR	Curr. Biol.	2003
11741534	C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1 Piwnica-Worms, H, Muller, J, Ory, S, Copeland, T, Morrison, DK	Mol Cell	2001
12932319	Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites Veenstra, TD, Ory, S, Zhou, M, Morrison, DK, Conrads, TP	Curr Biol	2003