Reactome | YWHAB dimer dissociates from KSR1:MARK3

YWHAB dimer dissociates from KSR1:MARK3

Stable Identifier

R-HSA-5672958

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Dephosphorylation of KSR1 S406 by PP2A promotes the dissociation of 14-3-3 from this site, exposing both the CR1 region that is required for membrane localization of KSR1 and the MAPK-binding FxFP motif (Ory et al, 2003; Muller et al, 2001; reviewed in Raabe and Raap, 2003).

Literature References

PubMed ID	Title	Journal	Year
12932339	Ras signaling: PP2A puts Ksr and Raf in the right place Raabe, T, Rapp, UR	Curr. Biol.	2003
11741534	C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1 Piwnica-Worms, H, Muller, J, Ory, S, Copeland, T, Morrison, DK	Mol Cell	2001
12932319	Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites Veenstra, TD, Ory, S, Zhou, M, Morrison, DK, Conrads, TP	Curr Biol	2003