Dephosphorylation of KSR1 S406 by PP2A promotes the dissociation of 14-3-3 from this site, exposing both the CR1 region that is required for membrane localization of KSR1 and the MAPK-binding FxFP motif (Ory et al, 2003; Muller et al, 2001; reviewed in Raabe and Raap, 2003).
Muller, J, Ory, S, Copeland, T, Piwnica-Worms, H, Morrison, DK
Raabe, T, Rapp, UR
Ory, S, Zhou, M, Conrads, TP, Veenstra, TD, Morrison, DK
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