MARK3-mediated phosphorylation of S311 and particularly S406 promotes the binding of 14-3-3 dimers, sequestering KSR1 in the cytosol in quiescent cells (Cacace et al, 1999; Muller et al, 2000; Muller et al, 2001; reviewed in Raabe and Raap, 2003). Mutation of S406 abrogates 14-3-3 binding and results in constitutive plasma membrane localization of KSR1 (Muller et al, 2001).
Muller, J, Cacace, AM, Lyons, WE, McGill, CB, Morrison, DK
Raabe, T, Rapp, UR
Muller, J, Ory, S, Copeland, T, Piwnica-Worms, H, Morrison, DK
Cacace, AM, Michaud, NR, Therrien, M, Mathes, K, Copeland, T, Rubin, GM, Morrison, DK
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