MARK3-mediated phosphorylation of S311 and particularly S406 promotes the binding of 14-3-3 dimers, sequestering KSR1 in the cytosol in quiescent cells (Cacace et al, 1999; Muller et al, 2000; Muller et al, 2001; reviewed in Raabe and Raap, 2003). Mutation of S406 abrogates 14-3-3 binding and results in constitutive plasma membrane localization of KSR1 (Muller et al, 2001).
Raabe, T, Rapp, UR
Muller, J, McGill, CB, Lyons, WE, Cacace, AM, Morrison, DK
Piwnica-Worms, H, Muller, J, Ory, S, Copeland, T, Morrison, DK
Rubin, GM, Copeland, T, Cacace, AM, Morrison, DK, Mathes, K, Michaud, NR, Therrien, M
© 2023 Reactome