p-S311,S406 KSR1:MARK3 binds YWHAB dimer

Stable Identifier
Homo sapiens
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MARK3-mediated phosphorylation of S311 and particularly S406 promotes the binding of 14-3-3 dimers, sequestering KSR1 in the cytosol in quiescent cells (Cacace et al, 1999; Muller et al, 2000; Muller et al, 2001; reviewed in Raabe and Raap, 2003). Mutation of S406 abrogates 14-3-3 binding and results in constitutive plasma membrane localization of KSR1 (Muller et al, 2001).

Literature References
PubMed ID Title Journal Year
12932339 Ras signaling: PP2A puts Ksr and Raf in the right place

Raabe, T, Rapp, UR

Curr. Biol. 2003
10891492 Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling

Muller, J, McGill, CB, Lyons, WE, Cacace, AM, Morrison, DK

Mol Cell Biol 2000
11741534 C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

Piwnica-Worms, H, Muller, J, Ory, S, Copeland, T, Morrison, DK

Mol Cell 2001
9858547 Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression

Rubin, GM, Copeland, T, Cacace, AM, Morrison, DK, Mathes, K, Michaud, NR, Therrien, M

Mol Cell Biol 1999
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