Reactome | p-S311,S406 KSR1:MARK3 binds YWHAB dimer

p-S311,S406 KSR1:MARK3 binds YWHAB dimer

Stable Identifier

R-HSA-5672954

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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p-S311,S406 KSR1:MARK3 binds YWHAB dimer

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MARK3-mediated phosphorylation of S311 and particularly S406 promotes the binding of 14-3-3 dimers, sequestering KSR1 in the cytosol in quiescent cells (Cacace et al, 1999; Muller et al, 2000; Muller et al, 2001; reviewed in Raabe and Raap, 2003). Mutation of S406 abrogates 14-3-3 binding and results in constitutive plasma membrane localization of KSR1 (Muller et al, 2001).

Literature References

PubMed ID	Title	Journal	Year
12932339	Ras signaling: PP2A puts Ksr and Raf in the right place Raabe, T, Rapp, UR	Curr. Biol.	2003
10891492	Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling Muller, J, Cacace, AM, Lyons, WE, McGill, CB, Morrison, DK	Mol Cell Biol	2000
11741534	C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1 Muller, J, Ory, S, Copeland, T, Piwnica-Worms, H, Morrison, DK	Mol Cell	2001
9858547	Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression Cacace, AM, Michaud, NR, Therrien, M, Mathes, K, Copeland, T, Rubin, GM, Morrison, DK	Mol Cell Biol	1999