Reactome | RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1

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RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10292304
displayName	RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
eventOf	[Pathway:R-CFA-5663220] RHO GTPases Activate Formins - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-5665999] MKL1 translocates from cytosol to the nucleus - Canis familiaris
inferredFrom	[Reaction:R-HSA-5665982] RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 - Homo sapiens
input	[Complex:R-CFA-5665986] EVL [cytosol] 2 × [Complex:R-CFA-5665995] Profilin:G-actin:MKL1 [cytosol] [Complex:R-CFA-5665988] RHOA:GTP:DIAPH1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
output	2 × [EntityWithAccessionedSequence:R-CFA-5665975] MRTFA [cytosol] [Complex:R-CFA-5665977] RHOA:GTP:DIAPH1:EVL:Profilin:G-actin [plasma membrane]
precedingEvent	[Reaction:R-CFA-5665989] DIAPH1 binds RHOA:GTP - Canis familiaris [Reaction:R-CFA-5666001] Profilin:G-actin binds MKL1 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5665982
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5663220] RHO GTPases Activate Formins
(precedingEvent)	[Reaction:R-CFA-5665999] MKL1 translocates from cytosol to the nucleus
(inferredTo)	[Reaction:R-HSA-5665982] RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1

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