Reactome | p-S90-BMAL1:p-T451,T461-CLOCK binds SERPINE1 gene

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p-S90-BMAL1:p-T451,T461-CLOCK binds SERPINE1 gene Show undefined attributes

authored	[InstanceEdit:5663109] May, Bruce, 2015-01-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5663103] May, Bruce, 2015-01-15
dbId	5663124
displayName	p-S90-BMAL1:p-T451,T461-CLOCK binds SERPINE1 gene
edited	[InstanceEdit:5663109] May, Bruce, 2015-01-14
eventOf	[Pathway:R-HSA-1368108] BMAL1:CLOCK,NPAS2 activates circadian expression - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-549364] Expression of SERPINE1 (PAI-1) - Homo sapiens
input	[Complex:R-HSA-9920661] p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-2106592] SERPINE1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:508365] Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference [LiteratureReference:549419] Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2 [LiteratureReference:549454] The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma PAI-1
maxDepth	1
modified	[InstanceEdit:9953423] May, Bruce, 2025-06-02
name	p-S90-BMAL1:p-T451,T461-CLOCK binds SERPINE1 gene
output	[Complex:R-HSA-5663104] p-S90-BMAL1:p-T451,T461-CLOCK:SERPINE1 gene [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9920665] p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:879756] Albrecht, Urs, 2010-06-23 [InstanceEdit:422151] D'Eustachio, P, 2009-05-26 22:13:22 [InstanceEdit:879786] Delaunay, F, 2010-06-23 [InstanceEdit:879790] Hirota, T, 2010-06-23 [InstanceEdit:879726] Kay, SA, 2010-06-23 [InstanceEdit:9953422] Albrecht, Urs, 2025-03-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5663124
summation	[Summation:549559] The phosphorylated BMAL1:CLOCK (ARNTL) heterodimer binds an ...
updateTrackers	[UpdateTracker:9953721] Update Tracker - [Reaction:5663124] p-S90-BMAL1:p-T451,T461-CLOCK binds SERPINE1 gene - v93:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9953721] Update Tracker - [Reaction:5663124] p-S90-BMAL1:p-T451,T461-CLOCK binds SERPINE1 gene - v93:[add_removeInput]
(precedingEvent)	[BlackBoxEvent:R-HSA-549364] Expression of SERPINE1 (PAI-1)
(hasEvent)	[Pathway:R-HSA-1368108] BMAL1:CLOCK,NPAS2 activates circadian expression

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