Reactome | p-S90-BMAL1:p-T451,T461-CLOCK:SERPINE1 gene [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5663103] May, Bruce, 2015-01-15
dbId	5663104
displayName	p-S90-BMAL1:p-T451,T461-CLOCK:SERPINE1 gene [nucleoplasm]
hasComponent	[Complex:R-HSA-9920661] p-S90-BMAL1:p-T451,T461-CLOCK [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-2106592] SERPINE1 gene [nucleoplasm]
inDisease	false
isChimeric	false
literatureReference	[LiteratureReference:508365] Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference [LiteratureReference:549419] Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2 [LiteratureReference:549454] The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma PAI-1
maxDepth	3
modified	[InstanceEdit:9940986] May, Bruce, 2025-03-06
name	p-S90-BMAL1:p-T451,T461-CLOCK:SERPINE1 gene
positivelyRegulates	[PositiveGeneExpressionRegulation:R-HSA-549564] Positive gene expression regulation by 'p-S90-BMAL1:p-T451,T461-CLOCK:SERPINE1 gene [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-5663124] p-S90-BMAL1:p-T451,T461-CLOCK binds SERPINE1 gene - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-5663104
updateTrackers	[UpdateTracker:9953903] Update Tracker - [Complex:5663104] p-S90-BMAL1:p-T451,T461-CLOCK:SERPINE1 gene [nucleoplasm] - v93:[add_removeHasComponent, modifyName]

(updatedInstance)	[UpdateTracker:9953903] Update Tracker - [Complex:5663104] p-S90-BMAL1:p-T451,T461-CLOCK:SERPINE1 gene [nucleoplasm] - v93:[add_removeHasComponent, modifyName]
(regulator)	[PositiveGeneExpressionRegulation:R-HSA-549564] Positive gene expression regulation by 'p-S90-BMAL1:p-T451,T461-CLOCK:SERPINE1 gene [nucleoplasm]'
(output)	[Reaction:R-HSA-5663124] p-S90-BMAL1:p-T451,T461-CLOCK binds SERPINE1 gene

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