Reactome | BMAL1:CLOCK,NPAS2 activates circadian expression

Schema > Pathway > Entries

BMAL1:CLOCK,NPAS2 activates circadian expression Show undefined attributes

authored	[InstanceEdit:1368114] May, B, 2011-06-22
compartment	[Compartment:7660] nucleoplasm [Compartment:984] extracellular region [Compartment:17957] endoplasmic reticulum lumen [Compartment:70101] cytosol
created	[InstanceEdit:1368132] May, B, 2011-06-29
dbId	1368108
displayName	BMAL1:CLOCK,NPAS2 activates circadian expression
doi	10.3180/R-HSA-1368108.8
edited	[InstanceEdit:1368114] May, B, 2011-06-22
eventOf	[TopLevelPathway:R-HSA-9909396] Circadian clock - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-5663165] p-S90-BMAL1:p-T451,T461-CLOCK binds AVP gene - Homo sapiens [BlackBoxEvent:R-HSA-879782] Expression of AVP - Homo sapiens [Reaction:R-HSA-5663170] p-S90-BMAL1:p-T451,T461-CLOCK binds BHLHE40 gene - Homo sapiens [BlackBoxEvent:R-HSA-879798] Expression of DEC1 (BHLHE40, BHLHB2) - Homo sapiens [Reaction:R-HSA-5663105] p-S90-BMAL1:p-T451,T461-CLOCK binds BHLHE41 (DEC2) gene - Homo sapiens [BlackBoxEvent:R-HSA-879770] Expression of DEC2 (BHLHE41, BHLHB3) - Homo sapiens [Reaction:R-HSA-5663127] p-S90-BMAL1:p-T451,T461-CLOCK,NPAS2 binds F7 gene - Homo sapiens [BlackBoxEvent:R-HSA-549428] Expression of FACTOR VII (F7) - Homo sapiens [Reaction:R-HSA-5663138] p-S90-BMAL1:p-T451,T461-CLOCK binds CCRN4L (NOCTURNIN) gene - Homo sapiens [BlackBoxEvent:R-HSA-549424] Expression of CCRN4L (NOCTURNIN) - Homo sapiens [Reaction:R-HSA-5663124] p-S90-BMAL1:p-T451,T461-CLOCK binds SERPINE1 gene - Homo sapiens [BlackBoxEvent:R-HSA-549364] Expression of SERPINE1 (PAI-1) - Homo sapiens [Reaction:R-HSA-5663156] p-S90-BMAL1:p-T451,T461-CLOCK binds PPARA gene - Homo sapiens [BlackBoxEvent:R-HSA-879724] Expression of PPARA - Homo sapiens [Reaction:R-HSA-5663122] p-S90-BMAL1:p-T451,T461-CLOCK binds NAMPT gene - Homo sapiens [BlackBoxEvent:R-HSA-1368889] Expression of NAMPT (NamPRT, PBEF, Visfatin) - Homo sapiens [Reaction:R-HSA-8878702] p-S90-BMAL1:p-T451,T461-CLOCK binds KLF15 gene - Homo sapiens [BlackBoxEvent:R-HSA-8878679] Expression of KLF15 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:1368115] The circadian E-box: when perfect is not good enough [LiteratureReference:508691] Role of the CLOCK protein in the mammalian circadian mechanism
maxDepth	2
modified	[InstanceEdit:9954121] Weiser, Joel, 2025-06-06
name	BMAL1:CLOCK,NPAS2 activates circadian expression
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:879756] Albrecht, Urs, 2010-06-23 [InstanceEdit:422151] D'Eustachio, P, 2009-05-26 22:13:22 [InstanceEdit:879786] Delaunay, F, 2010-06-23 [InstanceEdit:879790] Hirota, T, 2010-06-23 [InstanceEdit:879726] Kay, SA, 2010-06-23 [InstanceEdit:9940981] Albrecht, Urs, 2025-03-06
revised	[InstanceEdit:5663303] May, Bruce, 2015-01-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1368108
summation	[Summation:1368073] As inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:...
updateTrackers	[UpdateTracker:9788912] Update Tracker - [Pathway:1368108] BMAL1:CLOCK,NPAS2 activates circadian gene expression - v39:[addHasEvent, updateContainedRLE] [UpdateTracker:9779709] Update Tracker - [Pathway:1368108] BMAL1:CLOCK,NPAS2 activates circadian gene expression - v64:[removeHasEvent] [UpdateTracker:9785640] Update Tracker - [Pathway:1368108] BMAL1:CLOCK,NPAS2 activates circadian gene expression - v51:[updateContainedRLE] [UpdateTracker:9787222] Update Tracker - [Pathway:1368108] BMAL1:CLOCK,NPAS2 activates circadian gene expression - v46:[modifyText, updateContainedRLE] [UpdateTracker:9782834] Update Tracker - [Pathway:1368108] BMAL1:CLOCK,NPAS2 activates circadian gene expression - v58:[addHasEvent, updateContainedRLE] [UpdateTracker:9776027] Update Tracker - [Pathway:1368108] BMAL1:CLOCK,NPAS2 activates circadian gene expression - v78:[updateContainedRLE] [UpdateTracker:9788723] Update Tracker - [Pathway:1368108] BMAL1:CLOCK,NPAS2 activates circadian gene expression - v40:[updateContainedRLE] [UpdateTracker:9785461] Update Tracker - [Pathway:1368108] BMAL1:CLOCK,NPAS2 activates circadian gene expression - v52:[addHasEvent, updateContainedRLE] [UpdateTracker:9939696] Update Tracker - [Pathway:1368108] BMAL1:CLOCK,NPAS2 activates circadian expression - v92:[addHasEvent]

Referrals

(updatedInstance)

(hasEvent)

[TopLevelPathway:R-HSA-9909396] Circadian clock

Cite Us!