KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3

Stable Identifier
Reaction [transition]
Homo sapiens
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All characterized lysine demethylases other than KDM1A belong to the jumonjiC domain (JmjC) containing family.The JmjC KDMs are members of the Cupin superfamily of mononuclear Fe (II) dependent oxygenases, which are characterized by the presence of a double-stranded beta-helix core fold. The JmjC KDMs require 2 oxoglutarate (2 OG) and molecular oxygen as co substrates, producing, along with formaldehyde, succinate and carbon dioxide. This hydroxylation based mechanism does not require a protonatable lysine e amine group and consequently JmjC containing demethylases are able to demethylate tri , di and monomethylated lysines.
KDM4A-D (JMJD2A-D/JHDM3A-D) catalyse the demethylation of di- or tri-methylated histone H3 at lysine-10 (H3K9Me2/3) (Cloos et al. 2006, Fodor et al. 2006, Whetstine et al. 2007), with a strong preference for Me3 (Whetstine et al. 2007). MINA, a bifunctional histone lysine demethylase and ribosomal histidine hydroxylase, demethylates trimethylated lysine-10 of histone H3 (Lu et al. 2009). KDM4A (JHDM3A) can also demethylate lysine-37 of histone H3 (H3K36Me2/3) (Klose et al. 2006).
Literature References
PubMed ID Title Journal Year
16738407 Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells

Jenuwein, T, Opravil, S, Perez-Burgos, L, Mechtler, K, Sengupta, R, O'Sullivan, RJ, Schotta, G, Fodor, BD, Yonezawa, M, Kubicek, S

Genes Dev. 2006
19502796 Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3

Zhang, Y, Castranova, V, Shi, X, Chang, Q, Zhao, H, Beezhold, K, Chen, F, Rojanasakul, Y, Lu, Y

Cell Cycle 2009
16732293 The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

Helin, K, Christensen, J, Agger, K, Hansen, KH, Rappsilber, J, Cloos, PA, Maiolica, A, Antal, T

Nature 2006
16603238 Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

Spooner, E, Smolikov, S, Shi, Y, Lan, F, Chen, Z, Zhang, G, Li, E, Huarte, M, Colaiácovo, MP, Nottke, A, Whetstine, JR

Cell 2006
Catalyst Activity

histone demethylase activity of KDM4A, KDM4B, KDM4C, KDM4D, MINA [nucleoplasm]

Orthologous Events
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