Reactome | Response to metal ions

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Response to metal ions Show undefined attributes

authored	[InstanceEdit:5660523] May, Bruce, 2014-12-27
created	[InstanceEdit:5660497] May, Bruce, 2015-01-04
dbId	5660526
displayName	Response to metal ions
doi	10.3180/r-hsa-5660526.2
edited	[InstanceEdit:5660523] May, Bruce, 2014-12-27
eventOf	[TopLevelPathway:R-HSA-8953897] Cellular responses to stimuli - Homo sapiens
figure	[Figure:9628891] /figures/ehld/R-HSA-5660526.svg
goBiologicalProcess	[GO_BiologicalProcess:78245] response to metal ion
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-5660489] MTF1 activates gene expression - Homo sapiens [Pathway:R-HSA-5661231] Metallothioneins bind metals - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:5674730] Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review) [LiteratureReference:5674677] The taste of heavy metals: gene regulation by MTF-1 [LiteratureReference:5674649] Mechanisms of mammalian zinc-regulated gene expression [LiteratureReference:5674785] Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1)
maxDepth	3
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Response to metal ions
orthologousEvent	[Pathway:R-GGA-5660526] Response to metal ions - Gallus gallus [Pathway:R-DRE-5660526] Response to metal ions - Danio rerio [Pathway:R-SSC-5660526] Response to metal ions - Sus scrofa [Pathway:R-BTA-5660526] Response to metal ions - Bos taurus [Pathway:R-CFA-5660526] Response to metal ions - Canis familiaris [Pathway:R-RNO-5660526] Response to metal ions - Rattus norvegicus [Pathway:R-MMU-5660526] Response to metal ions - Mus musculus
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6798577] Atrian, S�lvia, 2015-09-19
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5660526
summation	[Summation:5683564] Though metals such as zinc, copper, and iron are required as...
updateTrackers	[UpdateTracker:9781712] Update Tracker - [Pathway:5660526] Response to metal ions - v60:[addHasEvent] [UpdateTracker:9775754] Update Tracker - [Pathway:5660526] Response to metal ions - v78:[updateIndirectRLE] [UpdateTracker:9780819] Update Tracker - [Pathway:5660526] Response to metal ions - v62:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781712] Update Tracker - [Pathway:5660526] Response to metal ions - v60:[addHasEvent] [UpdateTracker:9775754] Update Tracker - [Pathway:5660526] Response to metal ions - v78:[updateIndirectRLE] [UpdateTracker:9780819] Update Tracker - [Pathway:5660526] Response to metal ions - v62:[modifyText]
(hasEvent)	[TopLevelPathway:R-HSA-8953897] Cellular responses to stimuli