Reactome | MTF1 activates gene expression

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MTF1 activates gene expression Show undefined attributes

authored	[InstanceEdit:5660523] May, Bruce, 2014-12-27
created	[InstanceEdit:5660497] May, Bruce, 2015-01-04
dbId	5660489
displayName	MTF1 activates gene expression
edited	[InstanceEdit:5660523] May, Bruce, 2014-12-27
eventOf	[Pathway:R-HSA-5660526] Response to metal ions - Homo sapiens
followingEvent	[Pathway:R-HSA-5661231] Metallothioneins bind metals - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-5660479] MTF1 dimer:12Zn2+ binds SNCB gene (beta-synuclein) - Homo sapiens [BlackBoxEvent:R-HSA-5660530] Expression of SNCB - Homo sapiens [Reaction:R-HSA-5660514] MTF1 dimer:12Zn2+ binds CSRP1 gene - Homo sapiens [BlackBoxEvent:R-HSA-5660503] Expression of CSRP1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:5674649] Mechanisms of mammalian zinc-regulated gene expression [LiteratureReference:5674677] The taste of heavy metals: gene regulation by MTF-1 [LiteratureReference:5674770] Metal-responsive transcription factor-1 (MTF-1) selects different types of metal response elements at low vs. high zinc concentration [LiteratureReference:5674785] Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1) [LiteratureReference:8954367] Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc [LiteratureReference:5674730] Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review) [LiteratureReference:8954375] Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level
maxDepth	2
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	MTF1 activates gene expression
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959589] Ford, Dianne, 2017-01-27 [InstanceEdit:8959588] Wang, Qinglu, 2017-01-27
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5660489
summation	[Summation:5674979] The MTF1:zinc complex in the nucleus binds Metal Response El...
updateTrackers	[UpdateTracker:9775928] Update Tracker - [Pathway:5660489] MTF1 activates gene expression - v78:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9775928] Update Tracker - [Pathway:5660489] MTF1 activates gene expression - v78:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-5660526] Response to metal ions
(precedingEvent)	[Pathway:R-HSA-5661231] Metallothioneins bind metals