Once activated, the FGFR signaling pathway is regulated by n...

created [InstanceEdit:1503117] Rothfels, K, 2011-08-23
dbId 1503116
displayName Once activated, the FGFR signaling pathway is regulated by n...
modified [InstanceEdit:1503122] Rothfels, K, 2011-08-23
schemaClass Summation
text Once activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-mediated inhibition of FRS2-tyrosine phosphorylation and the attenuation of ERK signaling through the action of dual-specificity phosphatases, IL17RD/SEF, Sprouty and Spred proteins. A number of these inhibitors are themselves transcriptional targets of the activated FGFR pathway.
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