Reactome | SHC-mediated cascade:FGFR2

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SHC-mediated cascade:FGFR2 Show undefined attributes

authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5654694] Rothfels, Karen, 2014-12-03
crossReference	[DatabaseIdentifier:12819507] BioModels Database:BIOMD0000000466 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468 [DatabaseIdentifier:12819485] BioModels Database:BIOMD0000000424
dbId	5654699
deleted	[Deleted:5655577] Deletion of instance: 190346
displayName	SHC-mediated cascade:FGFR2
edited	[InstanceEdit:500337] Jupe, S, 2010-02-03
eventOf	[Pathway:R-HSA-5654696] Downstream signaling of activated FGFR2 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5654404] Activated FGFR2 binds SHC1 - Homo sapiens [Reaction:R-HSA-5654407] Activated FGFR2 phosphorylates SHC1 - Homo sapiens [Reaction:R-HSA-5654406] Activated FGFR2:p-SHC1 binds GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-12-21
literatureReference	[LiteratureReference:191036] Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells [LiteratureReference:190609] Cellular signaling by fibroblast growth factor receptors [LiteratureReference:532248] Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2) [LiteratureReference:191526] Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein. [LiteratureReference:532255] Fibroblast growth factor receptors have different signaling and mitogenic potentials
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	SHC-mediated cascade:FGFR2
orthologousEvent	[Pathway:R-MMU-5654699] SHC-mediated cascade:FGFR2 - Mus musculus [Pathway:R-CEL-5654699] SHC-mediated cascade:FGFR2 - Caenorhabditis elegans [Pathway:R-DME-5654699] SHC-mediated cascade:FGFR2 - Drosophila melanogaster [Pathway:R-GGA-5654699] SHC-mediated cascade:FGFR2 - Gallus gallus [Pathway:R-XTR-5654699] SHC-mediated cascade:FGFR2 - Xenopus tropicalis [Pathway:R-DRE-5654699] SHC-mediated cascade:FGFR2 - Danio rerio [Pathway:R-SSC-5654699] SHC-mediated cascade:FGFR2 - Sus scrofa [Pathway:R-BTA-5654699] SHC-mediated cascade:FGFR2 - Bos taurus [Pathway:R-CFA-5654699] SHC-mediated cascade:FGFR2 - Canis familiaris [Pathway:R-RNO-5654699] SHC-mediated cascade:FGFR2 - Rattus norvegicus
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5654699
summation	[Summation:532260] The exact role of SHC1 in FGFR signaling remains unclear. ...
updateTrackers	[UpdateTracker:9782094] Update Tracker - [Pathway:5654699] SHC-mediated cascade:FGFR2 - v59:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9782094] Update Tracker - [Pathway:5654699] SHC-mediated cascade:FGFR2 - v59:[updateContainedRLE]
(replacementInstances)	[Deleted:5655577] Deletion of instance: 190346
(hasEvent)	[Pathway:R-HSA-5654696] Downstream signaling of activated FGFR2

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