Reactome | SHC-mediated cascade:FGFR2

Schema > Pathway > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10650026
displayName	SHC-mediated cascade:FGFR2
eventOf	[Pathway:R-DRE-5654696] Downstream signaling of activated FGFR2 - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Danio rerio
inferredFrom	[Pathway:R-HSA-5654699] SHC-mediated cascade:FGFR2 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	SHC-mediated cascade:FGFR2
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-5654699
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-5654696] Downstream signaling of activated FGFR2
(inferredTo)	[Pathway:R-HSA-5654699] SHC-mediated cascade:FGFR2

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