Reactome | Activated FGFR2 binds SHC1

Activated FGFR2 binds SHC1

Stable Identifier

R-HSA-5654404

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR2 (Homo sapiens)
      - Downstream signaling of activated FGFR2 (Homo sapiens)
        
        SHC-mediated cascade:FGFR2 (Homo sapiens)
        
        Activated FGFR2 binds SHC1 (Homo sapiens)

General

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Although a role for SHC1 in FGF signalling has been implicated in many studies, it is not clear that SHC1 interacts directly with the receptor.

Literature References

PubMed ID	Title	Journal	Year
9480847	Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells Curto, M, Frankel, P, Carrero, A, Foster, DA	Biochem Biophys Res Commun	1998
7559490	Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells Klint, P, Kanda, S, Claesson-Welsh, L	J Biol Chem	1995
9045692	Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein. Kanai, M, Goke, M, Tsunekawa, S, Podolsky, DK	J Biol Chem	1997
18840094	Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2) Schüller, AC, Ahmed, Z, Levitt, JA, Suen, KM, Suhling, K, Ladbury, JE	Biochem J	2008