LIG1 binds POLB at long-patch BER site

Stable Identifier
R-HSA-5651773
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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DNA ligase I (LIG1) binds DNA polymerase beta (POLB) at the long-patch base excision repair (BER) site. LIG1 and POLB interact through their N-terminal domains (Prasad et al. 1996, Dimitriadis et al. 1998, Tomkinson et al. 2001, Ranalli et al. 2002, Balakrishnan et al. 2009).

Literature References
PubMed ID Title Journal Year
12200445 AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair.

Ranalli, TA, Tom, S, Bambara, RA

J Biol Chem 2002
11554294 Completion of base excision repair by mammalian DNA ligases

Tomkinson, AE, Chen, L, Dong, Z, Leppard, JB, Levin, DS, Mackey, ZB, Motycka, TA

Prog. Nucleic Acid Res. Mol. Biol. 2001
19329425 Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex

Balakrishnan, L, Brandt, PD, Lindsey-Boltz, LA, Sancar, A, Bambara, RA

J. Biol. Chem. 2009
9685411 Thermodynamics of human DNA ligase I trimerization and association with DNA polymerase beta

Dimitriadis, EK, Prasad, R, Vaske, MK, Chen, L, Tomkinson, AE, Lewis, MS, Wilson, SH

J. Biol. Chem. 1998
8663274 Specific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testis

Prasad, R, Singhal, RK, Srivastava, DK, Molina, JT, Tomkinson, AE, Wilson, SH

J. Biol. Chem. 1996
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