Reactome | LIG1 bound to POLB ligates SSB

Schema > Reaction > Entries

LIG1 bound to POLB ligates SSB Show undefined attributes

authored	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
catalystActivity	[CatalystActivity:5651794] DNA ligase activity of LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5651791] Orlic-Milacic, Marija, 2014-11-24
dbId	5651789
displayName	LIG1 bound to POLB ligates SSB
edited	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
eventOf	[Pathway:R-HSA-110362] POLB-Dependent Long Patch Base Excision Repair - Homo sapiens
followingEvent	[Reaction:R-HSA-5651792] LIG1 and POLB dissociate from repaired dsDNA - Homo sapiens
input	[Complex:R-HSA-5651769] LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5651761] Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex [LiteratureReference:111254] AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair. [LiteratureReference:5651775] Completion of base excision repair by mammalian DNA ligases [LiteratureReference:5651786] Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	LIG1 bound to POLB ligates SSB
orthologousEvent	[Reaction:R-SCE-5651789] LIG1 bound to POLB ligates SSB - Saccharomyces cerevisiae [Reaction:R-DDI-5651789] LIG1 bound to POLB ligates SSB - Dictyostelium discoideum [Reaction:R-GGA-5651789] LIG1 bound to POLB ligates SSB - Gallus gallus [Reaction:R-XTR-5651789] LIG1 bound to POLB ligates SSB - Xenopus tropicalis [Reaction:R-DRE-5651789] LIG1 bound to POLB ligates SSB - Danio rerio [Reaction:R-SSC-5651789] LIG1 bound to POLB ligates SSB - Sus scrofa [Reaction:R-BTA-5651789] LIG1 bound to POLB ligates SSB - Bos taurus [Reaction:R-CFA-5651789] LIG1 bound to POLB ligates SSB - Canis familiaris [Reaction:R-RNO-5651789] LIG1 bound to POLB ligates SSB - Rattus norvegicus [Reaction:R-MMU-5651789] LIG1 bound to POLB ligates SSB - Mus musculus
output	[Complex:R-HSA-5651790] LIG1:POLB:dsDNA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5651773] LIG1 binds POLB at long-patch BER site - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5651789
summation	[Summation:5651793] LIG1 (DNA ligase I), recruited to the long-patch base excisi...

Referrals

(hasEvent)	[Pathway:R-HSA-110362] POLB-Dependent Long Patch Base Excision Repair
(precedingEvent)	[Reaction:R-HSA-5651792] LIG1 and POLB dissociate from repaired dsDNA