EGFRvIII cancer variant does not bind EGF ligand

Stable Identifier
R-HSA-5638137
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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EGFRvIII mutant lacks the ligand binding domain and is therefore unable to bind EGFR ligands (Fernandes et al. 2001).

Participants
Participates
Normal reaction
Functional status

Loss of function of EGFRvIII mutant:HSP90:CDC37 [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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