EGFRvIII cancer variant does not bind EGF ligand

Stable Identifier
R-HSA-5638137
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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EGFRvIII cancer variant does not bind EGF ligand
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EGFRvIII mutant lacks the ligand binding domain and is therefore unable to bind EGFR ligands (Fernandes et al. 2001).
Literature References
Participants
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Participates
as an event of
Normal reaction
EGFR binds EGF ligand (Homo sapiens)
Functional status

Loss of function of EGFRvIII mutant:HSP90:CDC37 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2014-11-13)
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