Reactome | EGFRvIII cancer variant does not bind EGF ligand

EGFRvIII cancer variant does not bind EGF ligand

Stable Identifier

R-HSA-5638137

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

EGFRvIII cancer variant does not bind EGF ligand

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

EGFRvIII mutant lacks the ligand binding domain and is therefore unable to bind EGFR ligands (Fernandes et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11087732	Glycosylation-induced conformational modification positively regulates receptor-receptor association: a study with an aberrant epidermal growth factor receptor (EGFRvIII/DeltaEGFR) expressed in cancer cells Cohen, S, Fernandes, H, Bishayee, S	J Biol Chem	2001

Participants

Input

Participates

as an event of

Constitutive Signaling by EGFRvIII (Homo sapiens)

Normal reaction

EGFR binds EGF ligand (Homo sapiens)

Functional status

Loss of function of EGFRvIII mutant:HSP90:CDC37 [plasma membrane]

Normal Entity

EGFR [plasma membrane] (Homo sapiens)

Disease Entity

EGFR [plasma membrane] (Homo sapiens)

Status

loss of function via inframe deletion

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Authored

Orlic-Milacic, M (2011-11-04)

Reviewed

Greulich, H (2011-11-15)

Savas, S (2011-11-15)

Created

Orlic-Milacic, M (2014-11-13)

Cite Us!