EGFRvIII cancer variant does not bind EGF ligand

Stable Identifier
R-HSA-5638137
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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EGFRvIII cancer variant does not bind EGF ligand
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EGFRvIII mutant lacks the ligand binding domain and is therefore unable to bind EGFR ligands (Fernandes et al. 2001).
Literature References
Participants
Input
Participates
as an event of
Normal reaction
EGFR binds EGF ligand (Homo sapiens)
Functional status

Loss of function of EGFRvIII mutant:HSP90:CDC37 [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2014-11-13)
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