Based on the wild-type EGFR signaling, it is assumed that the guanine nucleotide exchange factor SOS1 interacts with phosphorylated EGFRvIII mutant through the adaptor protein, GRB2. Upon formation of this complex, SOS1 activates RAS by promoting GDP release and GTP binding. Although this reaction has not been directly confirmed for EGFRvIII cancer mutant, RAS-MAPK signaling cascade is activated in cells expressing EGFRvIII (Montgomery et al.1995).
Stahl, WL, Montgomery, RB, Moscatello, DK, Cooper, JA, Wong, AJ
guanyl-nucleotide exchange factor activity of p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane]
Gain of function of p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane]
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