Hh-dependent expression of GLI1 gene

Stable Identifier
R-HSA-5635853
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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Hh-dependent expression of GLI1 gene
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GLI1 expression is promoted by the binding of the full-length GLI transcription factors to consensus GLI sites in the promoter in response to Hh signaling (Dai et al, 1999; Bai et al, 2002; Bai et al, 2004; Vokes et al, 2007; Vokes et al, 2008; Lee et al, 2010).
Literature References
PubMed ID Title Journal Year
14723851 All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

Stephen, D, Joyner, AL, Bai, CB

Dev. Cell 2004
10075717 Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3

Ishii, S, Dai, P, Nakafuku, M, Maekawa, T, Akimaru, H, Tanaka, Y

J. Biol. Chem. 1999
17442700 Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

Davidson, EH, Giles, S, Wong, WH, Longabaugh, WJ, McCuine, S, McMahon, AP, Ji, H, Tenzen, T, Vokes, SA, Zhong, S

Development 2007
18832070 A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

Wong, WH, McMahon, AP, Ji, H, Vokes, SA

Genes Dev. 2008
12361967 Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

Stephen, D, Joyner, AL, Auerbach, W, Bai, CB, Lee, JS

Development 2002
20460306 Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis

Wong, WH, McMahon, AP, Ji, H, Scott, MP, Lee, EY, Vokes, SA, Ma, W, Ouyang, Z, Zhou, B

Proc. Natl. Acad. Sci. U.S.A. 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
2p-GLI:GLI1 gene [nucleoplasm] (Homo sapiens)
Active Unit
2p-GLI1,2,3 [nucleoplasm]
Authored
Rothfels, K  (2014-10-31)
Reviewed
Liu, Y C  (2014-11-09)
Created
Rothfels, K  (2014-11-07)
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