TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2

Stable Identifier
R-HSA-5635741
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
TNFRSF10D binds TNFRSF10A or TNFRSF10B
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TNFRSF10D (also known as DcR2 or TRAILR4) inhibits pro-apoptotic signaling by TRAIL (TNFSF10) receptors TNFRSF10A (TRAILR1, DR4) and TNFRSF10B (TRAILR2, DR5). TNFRSF10D has a truncated death domain (DD) but has the motifs involved in oligomerization of TRAIL receptors. While it was initially thought that TNFRSF10D functions as a decoy receptor that competes with TNFRSF10A and TNFRSF10B for ligand binding (Pan et al. 1997), latest studies indicate that it prevents TRAIL signaling by forming heterodimers with TNFRSF10A and TNFRSF10B and thus preventing formation of functional homotrimeric TRAIL ligand:receptor complexes (Neumann et al. 2014).

Literature References
PubMed ID Title Journal Year
9242610 An antagonist decoy receptor and a death domain-containing receptor for TRAIL

Pan, G, Ni, J, Wei, YF, Yu, G, Gentz, R, Dixit, VM

Science 1997
24764293 Dominant negative effects of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 4 on TRAIL receptor 1 signaling by formation of heteromeric complexes

Neumann, S, Hasenauer, J, Pollak, N, Scheurich, P

J. Biol. Chem. 2014
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created