Binding of TP53 (p53) to the NDRG1 gene promoter stimulates ...

created [InstanceEdit:5633313] Orlic-Milacic, Marija, 2014-10-31
dbId 5633315
displayName Binding of TP53 (p53) to the NDRG1 gene promoter stimulates ...
modified [InstanceEdit:6803269] Orlic-Milacic, Marija, 2015-10-05
schemaClass Summation
text Binding of TP53 (p53) to the NDRG1 gene promoter stimulates NDRG1 expression (Stein et al. 2004, Zhang et al. 2007). NDRG1 may positively regulate TP53-mediated apoptosis (Stein et al. 2004) or TP53-mediated cell cycle arrest (Zhang et al. 2007). The exact function of NDRG1 has not been elucidated. Most studies suggest that NDRG1 has a tumor suppressive role, but there are conflicting reports, showing that NDRG1 may act as an oncogene in some settings (reviewed by Liu et al. 2012, Sun and Cao 2013).
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