SMURF1/2 ubiquitinates PTCH1

Stable Identifier
Reaction [transition]
Homo sapiens
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SMURF 1 and 2 are required in a redundant manner for the ligand-dependent ubiquitination of the C-terminal tail of PTCH. Ubiquitination is required for PTCH1 clearance from the primary cilium to endocytic compartments for degradation, allowing downstream pathway activation (Rohatgi et al, 2007; Yue et al, 2014; Huang et al, 2013).

Literature References
PubMed ID Title Journal Year
24925320 Requirement of Smurf-mediated endocytosis of Patched1 in Sonic Hedgehog signal reception

Zhang, YE, Shen, QH, Tang, LY, Chen, Y, Yue, S, Zhang, Z, Tang, Y, Tang, Y, Ding, J, Cheng, SY, Yu, TT

Elife 2014
24302888 Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover

Wang, H, Liu, F, Sun, L, Chen, Z, Lv, X, Zhu, Y, Huang, S, Sun, Q, Lu, Y, Tao, Y, Zhang, C, Zhao, Y, Zhang, J, Zhang, Z, Yang, S, Zheng, X, Chen, D

PLoS Biol. 2013
17641202 Patched1 regulates hedgehog signaling at the primary cilium

Milenkovic, L, Rohatgi, R, Scott, MP

Science 2007
Catalyst Activity

ubiquitin protein ligase activity of PTCH1:SMURF [ciliary membrane]

Inferred From
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