Reactome | SMURF1/2 ubiquitinates PTCH1

SMURF1/2 ubiquitinates PTCH1

Stable Identifier

R-HSA-5632648

Type

Reaction [transition]

Species

Homo sapiens

Compartment

ciliary membrane

ReviewStatus

5/5

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SMURF 1 and 2 are required in a redundant manner for the ligand-dependent ubiquitination of the C-terminal tail of PTCH. Ubiquitination is required for PTCH1 clearance from the primary cilium to endocytic compartments for degradation, allowing downstream pathway activation (Rohatgi et al, 2007; Yue et al, 2014; Huang et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
24925320	Requirement of Smurf-mediated endocytosis of Patched1 in Sonic Hedgehog signal reception Zhang, YE, Shen, QH, Tang, LY, Chen, Y, Yue, S, Zhang, Z, Tang, Y, Tang, Y, Ding, J, Cheng, SY, Yu, TT	Elife	2014
24302888	Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover Wang, H, Liu, F, Sun, L, Chen, Z, Lv, X, Zhu, Y, Huang, S, Sun, Q, Lu, Y, Tao, Y, Zhang, C, Zhao, Y, Zhang, J, Zhang, Z, Yang, S, Zheng, X, Chen, D	PLoS Biol.	2013
17641202	Patched1 regulates hedgehog signaling at the primary cilium Milenkovic, L, Rohatgi, R, Scott, MP	Science	2007