SMURF1/2 ubiquitinates PTCH1

Stable Identifier
R-HSA-5632648
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SMURF 1 and 2 are required in a redundant manner for the ligand-dependent ubiquitination of the C-terminal tail of PTCH. Ubiquitination is required for PTCH1 clearance from the primary cilium to endocytic compartments for degradation, allowing downstream pathway activation (Rohatgi et al, 2007; Yue et al, 2014; Huang et al, 2013).

Literature References
PubMed ID Title Journal Year
24302888 Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover

Huang, S, Zhang, Z, Zhang, C, Lv, X, Zheng, X, Chen, Z, Sun, L, Wang, H, Zhu, Y, Zhang, J, Yang, S, Lu, Y, Sun, Q, Tao, Y, Liu, F, Zhao, Y, Chen, D

PLoS Biol. 2013
24925320 Requirement of Smurf-mediated endocytosis of Patched1 in Sonic Hedgehog signal reception

Yue, S, Tang, LY, Tang, Y, Tang, Y, Shen, QH, Ding, J, Chen, Y, Zhang, Z, Yu, TT, Zhang, YE, Cheng, SY

Elife 2014
17641202 Patched1 regulates hedgehog signaling at the primary cilium

Rohatgi, R, Milenkovic, L, Scott, MP

Science 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of PTCH1:SMURF [ciliary membrane]
Physical Entity
Activity
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