Reactome | Smurf1/2 ubiquitinates Ptch1

Schema > Reaction > Entries

authored	[InstanceEdit:5627765] Rothfels, Karen, 2014-10-20
catalystActivity	[CatalystActivity:5632640] ubiquitin protein ligase activity of Ptch1:Smurf1/2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5632643] Rothfels, Karen, 2014-10-28
dbId	5632644
displayName	Smurf1/2 ubiquitinates Ptch1
edited	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30
input	[Complex:R-MMU-5632595] Ptch1:Smurf1/2 [plasma membrane] [CandidateSet:R-MMU-517946] Ubiquitin [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5618035] Requirement of Smurf-mediated endocytosis of Patched1 in Sonic Hedgehog signal reception
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Smurf1/2 ubiquitinates Ptch1
orthologousEvent	[Reaction:R-HSA-5632648] SMURF1/2 ubiquitinates PTCH1 - Homo sapiens
output	[Complex:R-MMU-5632580] ub-Ptch1:Smurf1/2 [plasma membrane]
precedingEvent	[Reaction:R-MMU-5632642] Smurf1/2 bind Ptch1 - Mus musculus
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5636011] Liu, Yulu Cherry, 2014-11-09
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5632644
summation	[Summation:5632433] Mouse Ptch1 is ubiquitinated on its C-terminal tail in a Smu...

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