SESN1,2,3 bind overoxidized PRDX1

Stable Identifier
R-HSA-5631903
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Sestrins bind overoxidized PRDX1
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Sestrins (SESN1, SESN2 and likely SESN3) bind overoxidized PRDX1, in which the catalytic cysteine C52 has been converted to cysteine-sulfinic acid. Among all peroxiredoxins, PRDX1 is the most abundant member of the PRDX family. The major function is to protect cells against reactive oxygen species (ROS), thus impacting on cell proliferation and survival (Gong et al. 2015). While several reports state that sestrins reduce overoxidized PRDX1 to the catalytically active homodimer (Budanov et al. 2004, Papadia et al. 2008, Essler et al. 2009), there are conflicting reports claiming that sestrins do not possess cysteine sulfinyl reductase activity (Woo et al. 2009).

Literature References
PubMed ID Title Journal Year
15105503 Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

Budanov, AV, Sablina, AA, Feinstein, E, Koonin, EV, Chumakov, PM

Science 2004
25579166 Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma

Gong, F, Hou, G, Liu, H, Zhang, M

Med. Oncol. 2015
19113821 Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins

Woo, HA, Bae, SH, Park, S, Rhee, SG

Antioxid. Redox Signal. 2009
18344994 Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

Papadia, S, Soriano, FX, Léveillé, F, Martel, MA, Dakin, KA, Hansen, HH, Kaindl, A, Sifringer, M, Fowler, J, Stefovska, V, McKenzie, G, Craigon, M, Corriveau, R, Ghazal, P, Horsburgh, K, Yankner, BA, Wyllie, DJ, Ikonomidou, C, Hardingham, GE

Nat. Neurosci. 2008
19822145 Role of sestrin2 in peroxide signaling in macrophages

Essler, S, Dehne, N, Brüne, B

FEBS Lett. 2009
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created