Reactome | SESN1,2,3 bind overoxidized PRDX1

SESN1,2,3 bind overoxidized PRDX1

Stable Identifier

R-HSA-5631903

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Sestrins bind overoxidized PRDX1

ReviewStatus

5/5

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Sestrins (SESN1, SESN2 and likely SESN3) bind overoxidized PRDX1, in which the catalytic cysteine C52 has been converted to cysteine-sulfinic acid. Among all peroxiredoxins, PRDX1 is the most abundant member of the PRDX family. The major function is to protect cells against reactive oxygen species (ROS), thus impacting on cell proliferation and survival (Gong et al. 2015). While several reports state that sestrins reduce overoxidized PRDX1 to the catalytically active homodimer (Budanov et al. 2004, Papadia et al. 2008, Essler et al. 2009), there are conflicting reports claiming that sestrins do not possess cysteine sulfinyl reductase activity (Woo et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
25579166	Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR/p70S6K pathway in esophageal squamous cell carcinoma Gong, F, Hou, G, Liu, H, Zhang, M	Med. Oncol.	2015
15105503	Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD Budanov, AV, Sablina, AA, Feinstein, E, Koonin, EV, Chumakov, PM	Science	2004
19113821	Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins Woo, HA, Bae, SH, Park, S, Rhee, SG	Antioxid. Redox Signal.	2009
18344994	Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses Papadia, S, Soriano, FX, Léveillé, F, Martel, MA, Dakin, KA, Hansen, HH, Kaindl, A, Sifringer, M, Fowler, J, Stefovska, V, McKenzie, G, Craigon, M, Corriveau, R, Ghazal, P, Horsburgh, K, Yankner, BA, Wyllie, DJ, Ikonomidou, C, Hardingham, GE	Nat. Neurosci.	2008
19822145	Role of sestrin2 in peroxide signaling in macrophages Essler, S, Dehne, N, Brüne, B	FEBS Lett.	2009