Reactome | PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters

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PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters Show undefined attributes

authored	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24 [InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
catalystActivity	[CatalystActivity:5625786] protein serine/threonine kinase activity of p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643187] protein kinase C activity of p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm] Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5625787] Orlic-Milacic, Marija, 2014-10-07
dbId	5625784
displayName	PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters
edited	[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24
eventOf	[Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Homo sapiens
followingEvent	[Reaction:R-HSA-5625796] Demethylase KDM4C binds KLK2 and KLK3 promoters - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-5625776] p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5625775] Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters
orthologousEvent	[Reaction:R-DME-5625784] PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters - Drosophila melanogaster [Reaction:R-XTR-5625784] PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters - Xenopus tropicalis [Reaction:R-DRE-5625784] PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters - Danio rerio [Reaction:R-SSC-5625784] PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters - Sus scrofa [Reaction:R-BTA-5625784] PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters - Bos taurus [Reaction:R-CFA-5625784] PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters - Canis familiaris [Reaction:R-RNO-5625784] PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters - Rattus norvegicus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-5625782] p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5625774] PKN1:AR complex binds promoters of KLK2 and KLK3 genes - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5625784
summation	[Summation:5625785] PKN1 (PRK1), recruited to promoters of KLK2 and KLK3 (PSA) g...
systematicName	Complexed p-T774-PKN1 phosphorylates complexed Me3K-10-H3

Referrals

(hasEvent)	[Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
(precedingEvent)	[Reaction:R-HSA-5625796] Demethylase KDM4C binds KLK2 and KLK3 promoters

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