Reactome | PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters

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PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters Show undefined attributes

catalystActivity	[CatalystActivity:10515979] protein serine/threonine kinase activity of p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10515981
displayName	PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters
eventOf	[Pathway:R-SSC-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-5625796] Demethylase KDM4C binds KLK2 and KLK3 promoters - Sus scrofa
inferredFrom	[Reaction:R-HSA-5625784] PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-SSC-5625776] p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-SSC-5625782] p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3 [nucleoplasm]
precedingEvent	[Reaction:R-SSC-5625774] PKN1:AR complex binds promoters of KLK2 and KLK3 genes - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5625784
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
(precedingEvent)	[Reaction:R-SSC-5625796] Demethylase KDM4C binds KLK2 and KLK3 promoters
(inferredTo)	[Reaction:R-HSA-5625784] PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters

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