RAB3IP and RAB8A bind to the ciliary targeting complex

Stable Identifier
R-HSA-5623519
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RAB8A is another small GTPase that is required for ciliogenesis. RAB8A is recruited to the ciliary targeting complex at the trans-Golgi network (TGN) through interactions of the RAB8A guanine nucleotide exchange factor (GEF) RAB3IP (also known as RABIN8) with ASAP1 and RAB11 (Wang et al, 2012; Westlake et al, 2011; Feng et al, 2012; reviewed in Deretic, 2013). RAB8A is recruited in the inactive GDP bound form, and is activated at the TGN by RAB3IP in a RAB11A-dependent fashion (Hatulla et al, 2002; Knodler et al, 2010; Westlake et al, 2012; Wang et al, 2012; Feng et al, 2012).

Literature References
PubMed ID Title Journal Year
12221131 A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport

Hattula, K, Furuhjelm, J, Arffman, A, Peränen, J

Mol. Biol. Cell 2002
20308558 Coordination of Rab8 and Rab11 in primary ciliogenesis

Knödler, A, Feng, S, Zhang, J, Zhang, X, Das, A, Peränen, J, Guo, W

Proc. Natl. Acad. Sci. U.S.A. 2010
21273506 Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

Westlake, CJ, Baye, LM, Nachury, MV, Wright, KJ, Ervin, KE, Phu, L, Chalouni, C, Beck, JS, Kirkpatrick, DS, Slusarski, DC, Sheffield, VC, Scheller, RH, Jackson, PK

Proc. Natl. Acad. Sci. U.S.A. 2011
22433857 A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis

Feng, S, Knödler, A, Ren, J, Zhang, J, Zhang, X, Hong, Y, Huang, S, Peränen, J, Guo, W

J. Biol. Chem. 2012
22983554 The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting

Wang, J, Morita, Y, Mazelova, J, Deretic, D

EMBO J. 2012
23567335 Crosstalk of Arf and Rab GTPases en route to cilia

Deretic, D

Small GTPases 2013
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